{"id":"W4416624751","doi":"10.1002/alz.70930","title":"Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer Society; Cure Alzheimer's Fund; Alzheimer's Association","keywords":"Microglia; Induced pluripotent stem cell; In vivo; Disease; Phenotype; Amyloid (mycology); In vitro; Human brain","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002860776,0.0002895178,0.0001855954,0.0002033998,0.00016867,0.0002820747,0.00008480287,0.0002736207,0.001628766],"category_scores_gemma":[0.0001025419,0.0001153919,0.0001876306,0.0001440279,0.0001656937,0.0001255446,0.0001787571,0.0002415978,0.0006343766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001142286,"about_ca_system_score_gemma":0.0001404726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002248743,"about_ca_topic_score_gemma":0.0003656754,"domain_scores_codex":[0.9997968,0.00003995094,0.00001932248,0.00005326292,0.00005457897,0.00003609177],"domain_scores_gemma":[0.9999348,0.00001287042,0.00001451118,0.00001339329,0.00001368948,0.00001066168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002355823,0.00005906968,0.0007189938,0.00003816983,0.00001010836,0.0001335852,0.00007318951,0.00005022663,0.9966875,0.00006662044,0.00007951408,0.001847431],"study_design_scores_gemma":[0.0000877931,0.001722626,0.0284313,0.00003815659,0.0001122962,0.003254833,0.0002454281,0.001202905,0.9575422,0.0003262302,0.007014737,0.0000215393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911312,0.001975467,0.003476065,0.00008222973,0.00004136924,0.00008582671,0.0005366168,0.00005819584,0.00261297],"genre_scores_gemma":[0.9917207,0.001329295,0.003066113,0.000139165,0.0000278449,0.0002034129,0.001049207,0.00001701611,0.002447246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001628766,"threshold_uncertainty_score":0.005448759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0332773393678974,"score_gpt":0.2877175554039452,"score_spread":0.2544402160360478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}