{"id":"W4416630637","doi":"10.1016/j.jlb.2025.100409","title":"Plasma genotyping to identify novel resistance variants in advanced NSCLC(DISCOVER): Non-AGA report","year":2025,"lang":"en","type":"article","venue":"The Journal of Liquid Biopsy","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"European Commission","keywords":"Genotyping; Genotype; Mutation; Gene; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007531596,0.0001379927,0.0002139533,0.0001139305,0.00007118162,0.00003271019,0.000411607,0.00009102996,0.000004288242],"category_scores_gemma":[0.000423676,0.0001098284,0.0000917147,0.0002496454,0.00004210413,0.000008443886,0.0001781684,0.0001600186,0.00000290112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006847102,"about_ca_system_score_gemma":0.0003699543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002881852,"about_ca_topic_score_gemma":0.0002017962,"domain_scores_codex":[0.9988262,0.00003165029,0.000577693,0.0001852297,0.0001498439,0.0002293538],"domain_scores_gemma":[0.9989884,0.00005539466,0.0003119019,0.000397782,0.0001753734,0.00007110651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002534206,0.00006358481,0.000341853,0.00001722646,0.00006067747,0.00007533297,0.0001229854,0.001370686,0.9932217,0.0000850457,0.001846919,0.0002597645],"study_design_scores_gemma":[0.003914229,0.0008578979,0.08167397,0.0008588588,0.0001401493,0.0008895324,0.0006049303,0.00005501866,0.8617282,0.0002705732,0.04847419,0.0005324222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810508,0.001028696,0.01448304,0.001185052,0.0007563807,0.0001643767,0.00001911155,0.000001983538,0.001310581],"genre_scores_gemma":[0.9949123,0.0004678762,0.002797091,0.0006327653,0.0002717316,0.0000036276,0.000006273653,0.00001529631,0.0008930488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1314935,"threshold_uncertainty_score":0.447867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008781318783833907,"score_gpt":0.2909116107995188,"score_spread":0.2821302920156849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}