{"id":"W4416630726","doi":"10.1016/j.jlb.2025.100423","title":"Prognostic and Diagnostic Role of Circulating Tumor DNA (ctDNA) in High-risk Melanoma Patients: A Systematic Review and Meta-analysis","year":2025,"lang":"en","type":"article","venue":"The Journal of Liquid Biopsy","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Circulating tumor DNA; Melanoma; Circulating tumor cell; Biomarker; Disease; Adjuvant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009207386,0.0001459851,0.0009553678,0.000129469,0.00004217425,0.00001641343,0.0001775467,0.00004654473,0.000005163862],"category_scores_gemma":[0.00241852,0.00009039079,0.0002341687,0.0002894994,0.0000715007,0.000005358787,0.0001168099,0.000102119,2.033646e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001447564,"about_ca_system_score_gemma":0.00006059978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008128728,"about_ca_topic_score_gemma":0.00006109439,"domain_scores_codex":[0.9985895,0.0002568233,0.0007617865,0.0001358793,0.0001282929,0.0001277473],"domain_scores_gemma":[0.9982054,0.000510545,0.0007750433,0.0002570159,0.000202534,0.00004944608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00162286,0.001876649,0.4552977,0.1459054,0.2880774,0.000109972,0.001916223,0.002033919,0.1007904,0.001440681,0.0005207722,0.0004079432],"study_design_scores_gemma":[0.001877823,0.002446982,0.0940274,0.004577261,0.8826115,0.0001889123,0.0005692434,0.0001586955,0.01223104,0.0007294352,0.00004297872,0.0005387362],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8576126,0.1415932,0.00009440614,0.0002033705,0.00002147595,0.0004138206,0.00004400529,9.393887e-7,0.00001623792],"genre_scores_gemma":[0.9910256,0.008491017,0.0001482348,0.0002772073,0.00001745638,0.00001698416,0.000006475148,0.000008099115,0.000008906631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5945341,"threshold_uncertainty_score":0.368603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007194654326891107,"score_gpt":0.2352577677388859,"score_spread":0.2280631134119948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}