{"id":"W4416636002","doi":"10.1183/13993003.congress-2025.pa5890","title":"DUPILUMAB REDUCES SEVERE EXACERBATION RATES AND TOTAL IGE LEVELS IN CHILDREN WITH TYPE 2 ASTHMA, IRRESPECTIVE OF TRANSIENT INCREASE IN EOSINOPHILS","year":2025,"lang":"","type":"article","venue":"","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"","keywords":"Exacerbation; Eosinophil; Dupilumab; Asthma; Placebo; Immunoglobulin E; Eosinophil cationic protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002624652,0.0002136556,0.0003440062,0.00008528589,0.00008673612,0.000218256,0.0001640842,0.000255075,0.002611069],"category_scores_gemma":[0.0005374438,0.0001031474,0.000358125,0.00007963336,0.00007878993,0.0001661468,0.0001024729,0.0005267439,0.0003140515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272529,"about_ca_system_score_gemma":0.0002742104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002040657,"about_ca_topic_score_gemma":0.007763993,"domain_scores_codex":[0.9998679,0.00003923305,0.000009984913,0.00002232888,0.00002758453,0.00003299117],"domain_scores_gemma":[0.9997409,0.00006040888,0.00008848844,0.00001301085,0.00002716892,0.00007011965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.06308454,0.003782106,0.1944131,0.003147158,0.001086263,0.001328137,0.0003475311,0.001123424,0.09058745,0.0002421193,0.04363612,0.597222],"study_design_scores_gemma":[0.01114825,0.0395131,0.8915895,0.0006392879,0.001044429,0.004923773,0.0003455226,0.001858263,0.02044202,0.0001393079,0.02830599,0.00005051715],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981841,0.01214014,0.0002137819,0.0006309554,0.000121536,0.00009726952,0.00106795,0.00009969165,0.003787715],"genre_scores_gemma":[0.99181,0.003172832,0.0009545044,0.0009175563,0.0001089993,0.00009240946,0.001324185,0.00001930547,0.001600149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002611069,"threshold_uncertainty_score":0.008734882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008467393203707874,"score_gpt":0.2636931374034703,"score_spread":0.2552257441997624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}