{"id":"W4416637754","doi":"10.1183/13993003.congress-2025.pa479","title":"Efficacy and safety of add-on dupilumab vs inhaled corticosteroid (ICS) dose escalation in patients with asthma uncontrolled on medium-dose ICS/long-acting β2-agonist (LABA) – AIM4: Next Step study","year":2025,"lang":"","type":"article","venue":"","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Dupilumab; Exacerbation; Asthma; Adverse effect; Placebo; Clinical endpoint; Corticosteroid; Rescue therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003320027,0.001795959,0.002870485,0.0004194489,0.0005185081,0.001474383,0.001400816,0.002290431,0.007418173],"category_scores_gemma":[0.003129268,0.000883101,0.003565481,0.0003331679,0.001253549,0.0015705,0.0007224649,0.004609931,0.00157301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001363776,"about_ca_system_score_gemma":0.001972354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009271057,"about_ca_topic_score_gemma":0.001783829,"domain_scores_codex":[0.9985017,0.0007791136,0.0001248718,0.0001972349,0.0001384827,0.0002587333],"domain_scores_gemma":[0.99701,0.0007123518,0.0007265083,0.0002834677,0.0002075174,0.001060042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9632282,0.01937484,0.001007387,0.0002881727,0.0007259322,0.00002952318,0.00004246831,0.0002229869,0.00300602,0.00004269418,0.0007382815,0.01129349],"study_design_scores_gemma":[0.644595,0.3471113,0.00558678,0.00003627482,0.0008227908,0.00003463956,0.00002648491,0.0003702622,0.0007782127,0.00008489945,0.000527179,0.00002624284],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923518,0.001797518,0.0002542885,0.0005255992,0.0003550831,0.002085594,0.001091026,0.00005616532,0.001482856],"genre_scores_gemma":[0.9883966,0.001197815,0.001171084,0.001672136,0.0007999711,0.002996093,0.001621853,0.00002202632,0.002122376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007418173,"threshold_uncertainty_score":0.02481627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077766292628034,"score_gpt":0.2629497838824416,"score_spread":0.2521721209561613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}