{"id":"W4416638389","doi":"10.1183/13993003.congress-2025.pa4778","title":"Late Breaking Abstract - Dupilumab reduces the risk of severe exacerbations in patients with chronic obstructive pulmonary disease: results from BOREAS and NOTUS","year":2025,"lang":"","type":"article","venue":"","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McMaster University","funders":"","keywords":"Exacerbation; COPD; Placebo; Hazard ratio; Dupilumab; Post-hoc analysis; Coronavirus disease 2019 (COVID-19); Severity of illness","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003939495,0.0008639498,0.002172454,0.0002675739,0.0003231828,0.001715713,0.0006371718,0.0009344617,0.00932626],"category_scores_gemma":[0.00600725,0.0002900552,0.00744017,0.0002979968,0.000351481,0.0007581652,0.0006346654,0.001825343,0.0009113781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006698153,"about_ca_system_score_gemma":0.0009791944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663274,"about_ca_topic_score_gemma":0.005362261,"domain_scores_codex":[0.9981006,0.001122015,0.0001655806,0.0002006319,0.0002364932,0.0001746636],"domain_scores_gemma":[0.9965256,0.001158962,0.0008705275,0.0003126144,0.0006104604,0.0005218191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6638975,0.001555986,0.0132988,0.01603806,0.05278884,0.0001677071,0.0001529452,0.001118196,0.005535898,0.0007033032,0.03609584,0.208647],"study_design_scores_gemma":[0.4374278,0.1315622,0.2113089,0.007185403,0.1377297,0.0009360111,0.0004313629,0.003697118,0.004943761,0.002405998,0.06206703,0.0003047414],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6615125,0.2646952,0.002186863,0.01513909,0.006373788,0.002609555,0.02179886,0.000403092,0.02528102],"genre_scores_gemma":[0.949381,0.02642439,0.001465859,0.006687728,0.002864943,0.0006695781,0.005904787,0.0000754927,0.006526213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00932626,"threshold_uncertainty_score":0.0311994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007893039622147177,"score_gpt":0.2519858562432233,"score_spread":0.2440928166210762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}