{"id":"W4416638484","doi":"10.1183/13993003.congress-2025.pa487","title":"Mepolizumab reduces exacerbations and improves quality of life in COPD irrespective of severe exacerbation history: Pooled Phase III trial results","year":2025,"lang":"","type":"article","venue":"","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Mepolizumab; Exacerbation; COPD; Quality of life (healthcare); Odds ratio; Post-hoc analysis; Logistic regression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007429723,0.002023646,0.005827325,0.0005717793,0.0002976143,0.001859264,0.0007903912,0.001297777,0.003886472],"category_scores_gemma":[0.006276712,0.000644962,0.0097192,0.0009969871,0.0004722475,0.0009251795,0.0005822179,0.001847404,0.0007778828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006623956,"about_ca_system_score_gemma":0.0008851793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099138,"about_ca_topic_score_gemma":0.003406191,"domain_scores_codex":[0.997333,0.001562827,0.0003942157,0.0003152046,0.0002330623,0.0001617064],"domain_scores_gemma":[0.9973902,0.00093178,0.000846258,0.000348049,0.0002289291,0.0002548482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.6826433,0.001100408,0.007529067,0.01530678,0.2150067,0.0001190991,0.00009353576,0.001712319,0.004129466,0.0001424036,0.008307474,0.06390946],"study_design_scores_gemma":[0.6163363,0.03727034,0.05975256,0.002412427,0.2720812,0.0003698388,0.00008616827,0.001312306,0.001520562,0.0006158113,0.008104358,0.0001380448],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5907134,0.3620448,0.005749114,0.003197402,0.002483913,0.005223324,0.01939867,0.0005237891,0.01066551],"genre_scores_gemma":[0.9275908,0.0535257,0.002244902,0.002131653,0.001292463,0.002817871,0.007863201,0.0001054261,0.002428031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007429723,"threshold_uncertainty_score":0.03929257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04222413701267584,"score_gpt":0.3588334355374115,"score_spread":0.3166092985247356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}