{"id":"W4416641314","doi":"10.1016/j.revmed.2025.10.116","title":"Étude de phase Ib, multicentrique, en ouvert, avec escalade de dose évaluant la tolérance, la pharmacocinétique et la pharmacodynamie du mosunetuzumab administré par voie sous-cutanée chez des participants atteints d’un lupus érythémateux systémique","year":2025,"lang":"fr","type":"article","venue":"La Revue de Médecine Interne","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Connective tissue disease; Human immunodeficiency virus (HIV); Immunopathology; Sida; Lupus erythematosus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006050776,0.0009287157,0.002181479,0.0004410784,0.0005282223,0.00154322,0.0005681187,0.001429586,0.003581762],"category_scores_gemma":[0.004320013,0.0005141486,0.001974729,0.0005161699,0.0007848507,0.001107794,0.000338396,0.00185329,0.0006324553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001532572,"about_ca_system_score_gemma":0.002482626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001963692,"about_ca_topic_score_gemma":0.002594148,"domain_scores_codex":[0.9978201,0.001123361,0.0001954438,0.0003565948,0.0002624379,0.0002420358],"domain_scores_gemma":[0.9971178,0.0006560172,0.0007423639,0.0004868996,0.0005397756,0.0004572319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6508356,0.02913542,0.01313728,0.001753858,0.005675216,0.00013278,0.0007278401,0.002143149,0.1020126,0.0006711406,0.0028842,0.1908908],"study_design_scores_gemma":[0.293057,0.6207198,0.04388306,0.0002578596,0.00408332,0.0003921285,0.0001727742,0.0009741112,0.01607582,0.0004009489,0.01990631,0.00007688218],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753329,0.01088052,0.003929072,0.0006460832,0.0003232535,0.003874901,0.002128691,0.0001242464,0.002760412],"genre_scores_gemma":[0.9758013,0.003786998,0.006542513,0.001159786,0.0002462441,0.005006719,0.002743363,0.00005813354,0.004654943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006050776,"threshold_uncertainty_score":0.03199995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0160238846175941,"score_gpt":0.3627785825124223,"score_spread":0.3467546978948282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}