{"id":"W4416642664","doi":"10.1016/j.msard.2025.106886","title":"Six-year safety and efficacy outcomes with first-line ofatumumab in recently diagnosed treatment-naive patients with relapsing multiple sclerosis","year":2025,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Novartis Pharma; Novartis Animal Health; Novartis","keywords":"Multiple sclerosis; Ofatumumab; Natalizumab; Relapsing remitting; MEDLINE; Fingolimod","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002598366,0.0007461779,0.001227032,0.0005996296,0.0007344855,0.0001047622,0.0001524818,0.0003277016,0.00004638115],"category_scores_gemma":[0.001328934,0.0004958479,0.0001643088,0.001139106,0.0007251347,0.0002752517,0.000205096,0.0005770178,0.000008764628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003858233,"about_ca_system_score_gemma":0.0001257312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001701308,"about_ca_topic_score_gemma":0.008022436,"domain_scores_codex":[0.9963051,0.0001759251,0.0008196067,0.001182153,0.0005895788,0.0009276153],"domain_scores_gemma":[0.9968451,0.001749801,0.0002307409,0.0005970687,0.0002271932,0.0003500909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005310809,0.002145815,0.9348648,0.0001526306,0.0009297715,0.000007781078,0.001492804,0.0004557311,0.0001805886,0.00001269766,0.0001079794,0.05433859],"study_design_scores_gemma":[0.0805835,0.001447639,0.9107817,0.002882176,0.0002992379,8.689991e-7,0.001037902,0.001565535,0.00009134595,0.000008041242,0.0008047283,0.0004972843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909223,0.00182137,0.00005310503,0.002883721,0.0001413797,0.003152286,0.0001133374,0.0001680102,0.0007445047],"genre_scores_gemma":[0.9624999,0.03568118,0.0008624985,0.0001242455,0.00001304256,0.0001976596,0.0001824643,0.00009061226,0.0003484201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07527269,"threshold_uncertainty_score":0.9997493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02454122563384652,"score_gpt":0.2534625429958049,"score_spread":0.2289213173619584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}