{"id":"W4416651770","doi":"10.1073/pnas.2517552122","title":"Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Institute on Aging; Thailand Science Research and Innovation; Wellcome Trust; Canadian Institutes of Health Research; George E. Hewitt Foundation for Medical Research; National Science Foundation Graduate Research Fellowship Program; National Institute of Neurological Disorders and Stroke; American Heart Association; Bill and Melinda Gates Foundation; National Institutes of Health; National Science Foundation","keywords":"MFN2; Mitochondrion; mitochondrial fusion; DNAJA3; Signal transduction; Genetic screen; Drug repositioning; Mitochondrial respiratory chain; Mitochondrial DNA; Drug discovery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001308814,0.0001572421,0.0002301416,0.0003649058,0.0004366417,0.0001034034,0.001333554,0.00009369365,0.000005862617],"category_scores_gemma":[0.002434403,0.0001145571,0.00008109003,0.00153749,0.001106329,0.001255817,0.0003512407,0.0004102582,7.656001e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005819551,"about_ca_system_score_gemma":0.00006561939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004330141,"about_ca_topic_score_gemma":0.000001153872,"domain_scores_codex":[0.9970597,0.00006048014,0.0005053001,0.0006540357,0.00142679,0.0002936834],"domain_scores_gemma":[0.9986249,0.0006844532,0.0004754389,0.00002021861,0.0001567417,0.00003823015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005231156,0.000122863,0.0006708973,0.00003219512,0.000002253634,4.296717e-8,0.0005511633,0.002300717,0.9863126,0.009518609,0.0001228865,0.0003134385],"study_design_scores_gemma":[0.0002210608,0.00005299907,0.003976243,0.0002190813,0.000005002458,0.000002774178,0.0009379848,0.03421036,0.9098231,0.05041442,0.00002621758,0.0001107242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918936,0.00004934923,0.00001113188,0.00232473,0.0001020536,0.0004897104,0.00001282031,0.00003130428,0.005085269],"genre_scores_gemma":[0.9974223,0.00001131432,0.001771447,0.0006605186,0.00004260937,0.00001155593,8.991214e-8,0.000005478516,0.00007471252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07648949,"threshold_uncertainty_score":0.4671501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09257607448108464,"score_gpt":0.3246552681740798,"score_spread":0.2320791936929952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}