{"id":"W4416660271","doi":"10.1016/s0140-6736(25)01865-3","title":"Efficacy and safety of rocatinlimab for the treatment of moderate-to-severe atopic dermatitis in ROCKET-IGNITE and ROCKET-HORIZON: two global, double-blind, placebo-controlled, randomised phase 3 clinical trials","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada); University of British Columbia","funders":"Kyowa Hakko Kirin; Amgen","keywords":"Clinical trial; Atopic dermatitis; Phases of clinical research; Phase (matter); Clinical efficacy; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003396231,0.001697388,0.003670557,0.000497704,0.0004146008,0.001395057,0.001102011,0.002381278,0.003839933],"category_scores_gemma":[0.002203729,0.0007320546,0.003552629,0.0003915889,0.001698996,0.001475287,0.0003684256,0.003249616,0.0007975803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000796867,"about_ca_system_score_gemma":0.000800667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007669898,"about_ca_topic_score_gemma":0.001658436,"domain_scores_codex":[0.9986954,0.0007117091,0.00008925478,0.0001935303,0.0001246901,0.0001853624],"domain_scores_gemma":[0.9987948,0.0004359831,0.0002726505,0.00008662381,0.00008177752,0.0003281405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9646668,0.003561511,0.0005200783,0.001590777,0.001615826,0.00004021079,0.00006122504,0.0002432408,0.003983704,0.0001000765,0.0006684055,0.02294804],"study_design_scores_gemma":[0.9236902,0.06997769,0.003430999,0.00009316541,0.0009372554,0.00006919742,0.00003494932,0.00033557,0.0005623661,0.0001533985,0.0006828791,0.00003230379],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545295,0.03790649,0.0007200203,0.0009756025,0.0007803382,0.001856811,0.0006638029,0.0001617768,0.002405646],"genre_scores_gemma":[0.9862186,0.007566288,0.0009675585,0.001039765,0.0004976307,0.001152555,0.0007253408,0.00002642865,0.001805676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003839933,"threshold_uncertainty_score":0.0179612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08850148496045512,"score_gpt":0.4310269657189185,"score_spread":0.3425254807584633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}