{"id":"W4416663962","doi":"10.1073/pnas.2520664122","title":"Lamprey <i>FOXN1</i> rescues the block of thymic epithelial cell development in the mouse <i>Foxn1</i> -deficient thymic rudiment","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"HORIZON EUROPE European Research Council; Deutsche Forschungsgemeinschaft","keywords":"Lamprey; Vertebrate; Gene; Negative selection; Immune system; Transcription factor; Compartment (ship); Cell; Cell type; Autoimmunity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561825,0.0003512145,0.0002693353,0.00040384,0.0002167996,0.0003851411,0.0004166879,0.0004054483,0.002461209],"category_scores_gemma":[0.000100502,0.0002861856,0.0003238505,0.0001081164,0.0003608161,0.000188914,0.0004007622,0.001079975,0.0008106765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005253539,"about_ca_system_score_gemma":0.0003320587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002565046,"about_ca_topic_score_gemma":0.00463782,"domain_scores_codex":[0.9997494,0.00002447081,0.00003097545,0.00006081158,0.00007407884,0.00006019954],"domain_scores_gemma":[0.9997072,0.00002763291,0.00009400231,0.00002503946,0.00001824486,0.000127934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004028068,0.0000101968,0.0001255894,0.00002513211,0.000003329942,0.00004126081,0.00001571308,0.00004002202,0.9991105,0.0001052572,0.00003633864,0.0004463673],"study_design_scores_gemma":[0.00001616423,0.0001192286,0.007784243,0.00001566885,0.00002192583,0.0003043742,0.00006545083,0.001047613,0.9849935,0.00005258279,0.005571258,0.000007997714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931089,0.001033316,0.002188305,0.0001558465,0.00003818612,0.00001906252,0.000892536,0.0003135064,0.002250342],"genre_scores_gemma":[0.978726,0.0007649133,0.002168662,0.0001169401,0.00001427307,0.00003905843,0.001242271,0.000197673,0.01673022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002565046,"threshold_uncertainty_score":0.008233547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0187808217978069,"score_gpt":0.2549765962112281,"score_spread":0.2361957744134212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}