{"id":"W4416664169","doi":"10.1101/2025.11.22.689900","title":"WWOX deficiency uncovers a cell-autonomous mechanism impairing myelin repair","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lotte and John Hecht Memorial Foundation","keywords":"Remyelination; OLIG2; WWOX; Oligodendrocyte; Myelin; SOX10; Transcription factor; PEDF; Transcriptome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295057,0.0004500978,0.0002324972,0.0002480125,0.0001257518,0.0003446793,0.0002058963,0.0003609525,0.001321971],"category_scores_gemma":[0.0000805401,0.0001495466,0.0001884175,0.0001183644,0.0004234068,0.0001203804,0.0002990139,0.0004732393,0.0005624421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258867,"about_ca_system_score_gemma":0.0001808627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004912923,"about_ca_topic_score_gemma":0.0005712708,"domain_scores_codex":[0.9998882,0.00001049003,0.00001056104,0.00003480165,0.00003311575,0.00002279679],"domain_scores_gemma":[0.9999133,0.00001373209,0.00003141515,0.00001005616,0.000007611781,0.00002381713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003896724,0.000004349879,0.0001151675,0.00001318064,0.000002962297,0.0000789733,0.000005766874,0.00002303125,0.9992841,0.0000883524,0.00002244724,0.0003227485],"study_design_scores_gemma":[0.000006102373,0.00005242147,0.003530869,0.000004945751,0.00001861801,0.0004014548,0.00002823752,0.0006351173,0.9933809,0.0001546758,0.001783251,0.000003279987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901645,0.0009995595,0.006471804,0.0001325077,0.00004727358,0.0000152299,0.0007467801,0.0002044315,0.001218009],"genre_scores_gemma":[0.9916288,0.0007456055,0.002059035,0.00006149363,0.00001146869,0.00001361933,0.0005741838,0.00007975935,0.004825966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001321971,"threshold_uncertainty_score":0.004422426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0068229025728497,"score_gpt":0.2014360756194268,"score_spread":0.1946131730465771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}