{"id":"W4416664626","doi":"10.1182/bloodadvances.2025016812","title":"Outcomes following matched sibling donor transplantation for severe combined immunodeficiency: a report from the PIDTC","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital","funders":"NHLBI Division of Intramural Research; Children's Hospital of Pittsburgh; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Office of Naval Research; National Institutes of Health; Feinberg School of Medicine; Rare Diseases Clinical Research Network; Atara Biotherapeutics; Children's Healthcare of Atlanta; Saint Louis University; Children’s Hospital of Wisconsin Research Institute; National Center for Advancing Translational Sciences; Les Laboratories Pierre Fabre; Seattle Children's Research Institute; California Institute of Regenerative Medicine; University of Cincinnati; Children's National Hospital; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; University of Washington; Pfizer; Northwestern University; Health Resources and Services Administration; Texas Children's Hospital; University of Minnesota; Children's Hospital of Philadelphia; Children's Hospital Colorado; Amgen; Emory University; U.S. Department of Health and Human Services; Aflac; bluebird bio; Cincinnati Children's Hospital Medical Center","keywords":"Sibling; Transplantation; Severe combined immunodeficiency; Cohort; Conditioning regimen; Retrospective cohort study; Hematopoietic stem cell transplantation; Hematopoietic cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003890675,0.0002488514,0.0004128918,0.00008298796,0.0008126188,0.00004841424,0.0004629498,0.0001492781,0.00003779656],"category_scores_gemma":[0.0002069995,0.0001768561,0.0003218857,0.0002955736,0.0001322773,0.0002596379,0.00004325046,0.0002138857,0.00002130139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001418777,"about_ca_system_score_gemma":0.0001025615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002418221,"about_ca_topic_score_gemma":0.0000282595,"domain_scores_codex":[0.9984843,0.00009516424,0.000557576,0.0004060361,0.00004891662,0.0004079932],"domain_scores_gemma":[0.9984169,0.0008856321,0.0002033831,0.0004332333,0.00005710681,0.000003757771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001847234,0.002156347,0.2622327,0.0003923592,0.004432106,0.0000730747,0.01063718,0.001067579,0.6199465,0.009372937,0.0005078968,0.08733404],"study_design_scores_gemma":[0.03731767,0.0005432856,0.5019812,0.001171595,0.00408719,0.0001522364,0.02179343,0.00007700994,0.1771553,0.03154836,0.2218699,0.002302861],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8917147,0.097309,0.004443948,0.001214005,0.002515702,0.0007384995,0.00009095635,0.0001691705,0.001804001],"genre_scores_gemma":[0.9956713,0.0003742534,0.000267028,0.0004762696,0.000003542148,0.0001639058,0.0004942736,0.00001590699,0.002533481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4427913,"threshold_uncertainty_score":0.7211983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00712664970114236,"score_gpt":0.2575265043485186,"score_spread":0.2503998546473763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}