{"id":"W4416666989","doi":"10.1001/jamanetworkopen.2025.45578","title":"Proton Pump Inhibitor Use and Survival in Patients With Newly Diagnosed Glioblastoma","year":2025,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Glioblastoma; Adverse effect; Temozolomide; Overall survival; Proton-pump inhibitor; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266968,0.0001352532,0.0001689242,0.000037845,0.00008126292,0.0002520816,0.0002677157,0.0001280694,0.00001395537],"category_scores_gemma":[0.0001237637,0.0001106725,0.00002159472,0.000235858,0.00006328689,0.00002543717,0.0006230646,0.0001332001,0.000003287912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001498108,"about_ca_system_score_gemma":0.00009844175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001952268,"about_ca_topic_score_gemma":0.0006169719,"domain_scores_codex":[0.9988833,0.0001474443,0.0001608742,0.0003645171,0.0001331276,0.0003107299],"domain_scores_gemma":[0.9994568,0.00005546125,0.00004312618,0.0002868619,0.00008223218,0.00007547362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002556151,0.0001445376,0.9858988,0.00002392254,0.00004785646,0.00001585679,0.00001417529,0.0001598757,0.0006306975,0.00004093931,0.002755502,0.007711665],"study_design_scores_gemma":[0.007622665,0.001078028,0.9354135,0.0003209882,0.00001274075,3.512751e-7,0.00004408186,0.0001573177,0.01076264,0.000041724,0.04425294,0.0002930027],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973446,0.00009685946,0.0000661671,0.0002238456,0.0000597854,0.00143768,0.00001368201,0.000005537749,0.0007518715],"genre_scores_gemma":[0.9982151,0.00007654197,0.0002421164,0.0002875489,0.0001629328,0.0002137157,0.00007889292,0.0000175903,0.0007055551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05048531,"threshold_uncertainty_score":0.4513094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056193230575768,"score_gpt":0.2721897871458302,"score_spread":0.2616278548400725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}