{"id":"W4416674533","doi":"10.1021/acsmedchemlett.5c00593","title":"Structure–Activity and Cationic Amphiphilic Drug-like Behavior of Aromatic Triamino Glycosylated Antitumor Ether Lipids with Cytotoxicity in 2D and 3D Models","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Supramolecular Self-Assembly in Materials","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Cytotoxicity; Amphiphile; Doxorubicin; Cationic polymerization; Ether; Cisplatin; Drug; Viability assay","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004777386,0.0002639693,0.0005046187,0.00008901704,0.00006688364,0.00005436757,0.0002320037,0.0001176825,0.00004692558],"category_scores_gemma":[0.0000768519,0.0002262712,0.00002168978,0.0002455025,0.0003678718,0.0001914135,0.00008975905,0.0001857324,6.996884e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001010516,"about_ca_system_score_gemma":0.0001133903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000456367,"about_ca_topic_score_gemma":0.00004520891,"domain_scores_codex":[0.9983302,0.0001343386,0.0004008948,0.0004746413,0.0003587983,0.0003010814],"domain_scores_gemma":[0.9990823,0.0001544458,0.0002319991,0.0004066459,0.00004154463,0.00008309021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001567617,0.00005795541,0.003039981,0.0004135172,0.00001965547,0.00003481215,0.0002951446,0.00007212991,0.9957955,0.000007471322,0.00002340193,0.00008359751],"study_design_scores_gemma":[0.001421466,0.00002827966,0.01137473,0.0003199569,0.0001313519,0.00006485898,0.00008973452,0.0002563811,0.9859161,0.0001897558,0.000002152693,0.0002052678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984558,0.0001140672,0.0002519718,0.0005559736,0.0001237883,0.0003987544,0.00002173245,0.00004069395,0.00003726721],"genre_scores_gemma":[0.9987756,0.00001370848,0.0007875734,0.0002947348,0.00003962373,0.00004555588,0.00001132267,0.00001921753,0.00001266175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009879503,"threshold_uncertainty_score":0.9227073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006857416324103178,"score_gpt":0.2337793956078345,"score_spread":0.2269219792837313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}