{"id":"W4416674688","doi":"10.3390/ph18121789","title":"Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively","year":2025,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"CYP3A4; Gene isoform; Cytochrome P450; Isozyme; Microsome; In vitro; Human liver; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005651079,0.0006619261,0.0003313854,0.0008628849,0.0003156944,0.0005728492,0.00022358,0.0004836229,0.001585025],"category_scores_gemma":[0.0005082067,0.0002241822,0.0004507781,0.0008801315,0.0003433463,0.0003010672,0.0002574145,0.0005411779,0.0006501597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003521004,"about_ca_system_score_gemma":0.000277658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007960579,"about_ca_topic_score_gemma":0.0009771014,"domain_scores_codex":[0.9994208,0.00007309156,0.00005281948,0.0001951798,0.0002080924,0.00005010189],"domain_scores_gemma":[0.9997641,0.00003512981,0.00007158597,0.00002703548,0.0000861589,0.00001585892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001280778,0.00002075914,0.002713724,0.0001550706,0.00004346879,0.0000586614,0.00002832957,0.00007203547,0.9917819,0.00005449021,0.0001218803,0.004821577],"study_design_scores_gemma":[0.00001097583,0.0002052249,0.04664467,0.00002382632,0.0001136341,0.0008101962,0.00005528043,0.001358475,0.9470289,0.0001009484,0.00363285,0.0000149834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9293668,0.01001351,0.04961349,0.0005476872,0.0001125549,0.000163822,0.005634838,0.0005903407,0.00395693],"genre_scores_gemma":[0.9336005,0.006322342,0.04527463,0.0002897577,0.00008972817,0.0003161885,0.007248166,0.0001019295,0.006756761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585025,"threshold_uncertainty_score":0.005302489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1995758154935997,"score_gpt":0.4782149872267328,"score_spread":0.2786391717331332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}