{"id":"W4416675844","doi":"10.1002/anie.202516608","title":"The Histidine Kinase VraS Interacts with Vancomycin and Penicillins Through its Membrane‐Anchored N‐terminal Domain","year":2025,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Agencia Santafesina de Ciencia, Tecnología e Innovación; Consejo Nacional de Investigaciones Científicas y Técnicas; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Histidine kinase; Histidine; Extracellular; Penicillin binding proteins; Vancomycin; Staphylococcus aureus; Kinase; Mutant; Ampicillin; Protein kinase domain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000649502,0.0001996341,0.0001367952,0.00005845024,0.00007493657,0.0001728143,0.000121724,0.0001722099,0.0006762707],"category_scores_gemma":[0.00009228737,0.00007092451,0.0001600195,0.00005440904,0.0001309953,0.0001111924,0.0001409542,0.000184921,0.0002534143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002492494,"about_ca_system_score_gemma":0.000123095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006278501,"about_ca_topic_score_gemma":0.0005864617,"domain_scores_codex":[0.9999322,0.00001485743,0.000002831029,0.00001419967,0.00001721851,0.00001876664],"domain_scores_gemma":[0.9999763,0.000007035908,0.000006419012,0.000001858252,0.000002875936,0.000005491268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005765662,0.000008015687,0.0002421376,0.00002018606,0.000003984902,0.00003969216,0.000009428076,0.00007530432,0.9986752,0.0001093204,0.00001859022,0.0007406205],"study_design_scores_gemma":[0.00001259013,0.0002017296,0.006566557,0.000005264185,0.000009679494,0.0003792383,0.00005071499,0.002289868,0.9882826,0.00007804474,0.002114984,0.000008703775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967417,0.0008014033,0.001079685,0.00005986318,0.000009724729,0.000006201537,0.00005429644,0.00001319748,0.001233819],"genre_scores_gemma":[0.997685,0.0002801574,0.0007738703,0.00002072925,0.000002677411,0.000003554504,0.00007629857,0.000002358966,0.001155262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006762707,"threshold_uncertainty_score":0.002262354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173242486675907,"score_gpt":0.2818131989108579,"score_spread":0.2700807740440988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}