{"id":"W4416676490","doi":"10.1002/ange.202516608","title":"The Histidine Kinase VraS Interacts with Vancomycin and Penicillins Through its Membrane‐Anchored N‐terminal Domain","year":2025,"lang":"de","type":"article","venue":"Angewandte Chemie","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Agencia Santafesina de Ciencia, Tecnología e Innovación; Consejo Nacional de Investigaciones Científicas y Técnicas; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Histidine; Histidine kinase; Penicillin binding proteins; Extracellular; Mutant; Protein kinase domain; Kinase; Cell membrane; Vancomycin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007790862,0.0001893677,0.0000955627,0.00005894495,0.00007945624,0.0001472194,0.000156031,0.000170164,0.00101384],"category_scores_gemma":[0.0000889262,0.00006711835,0.0001235005,0.00005306298,0.0001250734,0.0000927233,0.0001313868,0.000228256,0.0003772732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003735819,"about_ca_system_score_gemma":0.0001221918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009149309,"about_ca_topic_score_gemma":0.0007842903,"domain_scores_codex":[0.9999368,0.0000157899,0.000003083845,0.00001204221,0.00001519419,0.0000170589],"domain_scores_gemma":[0.9999688,0.000008811005,0.000007504851,0.000002788833,0.000004017862,0.00000806311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006622536,0.000009424607,0.0001448861,0.00001880579,0.000003285434,0.00003718706,0.000006248765,0.00008086492,0.9990059,0.000146761,0.00002368763,0.0004568007],"study_design_scores_gemma":[0.00001897773,0.0001207004,0.004677603,0.000005770369,0.000006787255,0.0002484881,0.00003408971,0.002902292,0.9897619,0.00008362495,0.002132869,0.000006920343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996866,0.0004295075,0.001347183,0.00008009889,0.00001341849,0.000005576054,0.00009564711,0.00001729173,0.001145162],"genre_scores_gemma":[0.9975187,0.0001750913,0.0007821727,0.00002309572,0.000002367054,0.000004574502,0.0001542815,0.000003214791,0.001336644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101384,"threshold_uncertainty_score":0.003391623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008087946358960204,"score_gpt":0.2372108019452491,"score_spread":0.2291228555862889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}