{"id":"W4416681818","doi":"10.1101/2025.11.10.25339891","title":"As rates of ASD and ADHD rise, genetic contributions fall: Evidence for widening diagnostic criteria","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Lundbeckfonden; National Institutes of Health; H. Lundbeck A/S; Region Hovedstaden; National Institute of Mental Health; Novo Nordisk","keywords":"Medical diagnosis; Autism spectrum disorder; Autism; Genetic testing; Genetic diagnosis; Psychiatric diagnosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03187424,0.0004026393,0.0008348524,0.004120911,0.0005826267,0.001673542,0.002691636,0.001493484,0.003190651],"category_scores_gemma":[0.1199523,0.0004947319,0.001313088,0.003943324,0.002593434,0.002948016,0.002515943,0.001932439,0.0004648139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002428555,"about_ca_system_score_gemma":0.002888887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04254026,"about_ca_topic_score_gemma":0.04887784,"domain_scores_codex":[0.9789323,0.007973131,0.003701106,0.003987753,0.004817416,0.0005883816],"domain_scores_gemma":[0.8166527,0.1232451,0.03133354,0.007091148,0.01783843,0.003839226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003257496,0.00003649424,0.84517,0.002211163,0.0005833037,0.0001169505,0.001007832,0.0003516957,0.0002170022,0.00300774,0.01209321,0.1348789],"study_design_scores_gemma":[0.00004847505,0.0001253157,0.9692132,0.005018316,0.000479741,0.0006774827,0.001612974,0.0009696572,0.0001420705,0.004101199,0.01756909,0.00004252915],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.546393,0.3540497,0.01114267,0.06243725,0.00237923,0.0002236712,0.007130658,0.0002820791,0.01596176],"genre_scores_gemma":[0.9285796,0.04971679,0.006812623,0.009125113,0.0007890828,0.0001168385,0.004159785,0.00009154098,0.000608628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04254026,"threshold_uncertainty_score":0.1685691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029391029606484,"score_gpt":0.4259277166588491,"score_spread":0.3229886136982007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}