{"id":"W4416682897","doi":"10.1016/j.matbio.2025.11.007","title":"CCN1: a SASPy protein that plays multifaceted roles in fibrogenesis","year":2025,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Institute of Musculoskeletal Health and Arthritis; Natural Sciences and Engineering Research Council of Canada","keywords":"Matricellular protein; CYR61; Fibrosis; Phenotype; Pathological; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003836897,0.0004940154,0.0002204949,0.0003411171,0.0004461316,0.0004983447,0.0001952656,0.000558469,0.001633437],"category_scores_gemma":[0.000229492,0.00009456599,0.0002542819,0.0002356277,0.0003427692,0.000567555,0.0002820274,0.0004607967,0.0003871794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007378641,"about_ca_system_score_gemma":0.0005975358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000847716,"about_ca_topic_score_gemma":0.00127712,"domain_scores_codex":[0.9998832,0.00002404534,0.000007841793,0.00002002495,0.00004668465,0.00001818115],"domain_scores_gemma":[0.9998405,0.00002310928,0.00003615826,0.000008082136,0.00002737141,0.00006470727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002641474,0.00005201688,0.002857197,0.0007292925,0.00003675931,0.001551453,0.00009271993,0.0005392163,0.9436762,0.004603878,0.003364697,0.04223245],"study_design_scores_gemma":[0.00005847561,0.0006642165,0.0512039,0.0002597805,0.0001244032,0.01317386,0.0003107007,0.002959655,0.7135106,0.005038291,0.2126184,0.00007775159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6638302,0.2700058,0.01981045,0.01287025,0.001195712,0.0002869038,0.001525952,0.0004809856,0.02999373],"genre_scores_gemma":[0.9120702,0.05911782,0.0123644,0.001292454,0.0003445443,0.00008318712,0.001169225,0.00003942785,0.01351871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633437,"threshold_uncertainty_score":0.005464375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573036647474374,"score_gpt":0.3281273365053816,"score_spread":0.3123969700306378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}