{"id":"W4416682991","doi":"10.1016/j.toxlet.2025.111783","title":"DBDPE inhibits myogenic differentiation of C2C12 cells through inhibiting mitochondrial function and PI3K/AKT/mTOR signaling pathway","year":2025,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"National Key Research and Development Program of China","keywords":"C2C12; Apoptosis; Reactive oxygen species; Mitochondrion; Signal transduction; Cell signaling; Myocyte; Oxidative stress","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794874,0.0002122067,0.0002772978,0.00008427566,0.0001558454,0.00002440885,0.0001789956,0.0001859822,0.0008078466],"category_scores_gemma":[0.0001248133,0.000209622,0.00007084286,0.0003148237,0.0002974021,0.0002840279,0.0002657076,0.0002250948,0.00005930457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265579,"about_ca_system_score_gemma":0.00002618998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003248306,"about_ca_topic_score_gemma":0.00003869606,"domain_scores_codex":[0.9983675,0.0001605082,0.0004212039,0.0004288231,0.0002166457,0.0004053081],"domain_scores_gemma":[0.9993025,0.000166335,0.0002264722,0.0002354888,0.000002872596,0.00006635259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006914388,0.00005953522,0.002087904,0.00001157342,0.00003800193,0.000002791552,0.00033935,0.00009193519,0.9910221,0.00002898404,0.0008629595,0.005385768],"study_design_scores_gemma":[0.001062003,0.0001409835,0.03354693,0.00003553693,0.00006735556,0.000005421747,0.000085094,0.0001210485,0.9640607,0.0005119929,0.0001730442,0.0001899488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898058,0.00004432388,0.006614192,0.001762347,0.000936706,0.0003129401,0.00002448303,0.00006279811,0.0004364523],"genre_scores_gemma":[0.9961883,0.000004213922,0.0008268279,0.002706901,0.0001147491,0.000008350985,0.000002937119,0.00001911935,0.0001285749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03145903,"threshold_uncertainty_score":0.8845354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00809544671807729,"score_gpt":0.2130504070872118,"score_spread":0.2049549603691345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}