{"id":"W4416685541","doi":"10.1016/j.jcjd.2025.10.006","title":"Phase 3 ESSENCE Trial: Semaglutide in metabolic dysfunction-associated steatohepatitis (MASH)","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brampton Civic Hospital","funders":"","keywords":"Semaglutide; Steatohepatitis; Phase (matter); Steatosis; Metabolic disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009775809,0.001562257,0.00243597,0.0003414823,0.0003429258,0.001525615,0.0007690979,0.001419531,0.008947399],"category_scores_gemma":[0.000878537,0.0003819839,0.002830506,0.0003006296,0.0006873948,0.001030401,0.0004869479,0.003895739,0.001621604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008371698,"about_ca_system_score_gemma":0.001074547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001783828,"about_ca_topic_score_gemma":0.005594266,"domain_scores_codex":[0.9998094,0.00006469311,0.000008947504,0.00003133457,0.00002179177,0.00006376849],"domain_scores_gemma":[0.9996256,0.00006218297,0.00006711142,0.00002838764,0.00003157856,0.000185231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8788318,0.008750148,0.002963179,0.002182449,0.003461657,0.0001947043,0.0001064285,0.001601144,0.005870262,0.001172477,0.0170852,0.07778049],"study_design_scores_gemma":[0.9551778,0.03369509,0.005153849,0.0001230453,0.0008586951,0.0001236588,0.00005150223,0.0006873945,0.0004336354,0.0005150279,0.003149351,0.00003099074],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544563,0.01766539,0.001931593,0.004509331,0.001612458,0.002170607,0.00598404,0.0007392475,0.01093101],"genre_scores_gemma":[0.951171,0.00880883,0.003659904,0.009257278,0.0009602876,0.002850096,0.007284986,0.0001655416,0.01584205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008947399,"threshold_uncertainty_score":0.02993202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135803100605856,"score_gpt":0.2592693713810786,"score_spread":0.24791134037502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}