{"id":"W4416701844","doi":"10.1016/j.jtct.2025.11.016","title":"Genetic Findings of Potential Donor Origin in Cells Used for Cell and Gene Therapy: Recommendations from the World Marrow Donor Association","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services","funders":"","keywords":"Gene; Haematopoiesis; Cell; Genetic testing; Relevance (law); Genome editing; Transduction (biophysics); Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.05483658,0.001150431,0.001797671,0.005605742,0.001829121,0.003189139,0.005446681,0.01444005,0.007667181],"category_scores_gemma":[0.08485352,0.001108961,0.004850017,0.002937048,0.003274705,0.005628816,0.004442705,0.01541346,0.007544391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002349216,"about_ca_system_score_gemma":0.02164049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01109244,"about_ca_topic_score_gemma":0.01615846,"domain_scores_codex":[0.96333,0.01531748,0.01050304,0.001333506,0.007820799,0.001695124],"domain_scores_gemma":[0.8655974,0.05540726,0.01039719,0.004010932,0.05995668,0.004630695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001514227,0.0001808658,0.002098126,0.007535768,0.0001042728,0.001123858,0.0009614698,0.0004918898,0.001424876,0.01113398,0.7357248,0.2390686],"study_design_scores_gemma":[0.0001259104,0.00009296383,0.003095258,0.03043387,0.0002263163,0.00150779,0.0007956356,0.000226685,0.0005832163,0.008482475,0.9543236,0.0001061131],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.002349843,0.1164189,0.0401945,0.743115,0.02598903,0.004525439,0.002607295,0.001010936,0.06378896],"genre_scores_gemma":[0.01786941,0.192183,0.1571526,0.5707767,0.007779829,0.009152528,0.005653963,0.0004277368,0.0390042],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9855599,"threshold_uncertainty_score":0.2900071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618069703605344,"score_gpt":0.2706883135924937,"score_spread":0.2545076165564403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}