{"id":"W4416701844","doi":"10.1016/j.jtct.2025.11.016","title":"Genetic Findings of Potential Donor Origin in Cells Used for Cell and Gene Therapy: Recommendations from the World Marrow Donor Association","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services","funders":"","keywords":"Gene; Haematopoiesis; Cell; Genetic testing; Relevance (law); Genome editing; Transduction (biophysics); Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003118536,0.00009803503,0.0001718762,0.0001101795,0.00008210138,0.00002328219,0.00004312427,0.0001292732,0.00006434737],"category_scores_gemma":[0.000002000458,0.00007017691,0.00005200323,0.000187162,0.00007443393,0.00003331418,0.00000268956,0.0001253157,5.306375e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002525217,"about_ca_system_score_gemma":0.00005229716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001565669,"about_ca_topic_score_gemma":0.0001732743,"domain_scores_codex":[0.9992343,0.00007881237,0.0002723232,0.0001723917,0.0001317896,0.0001103519],"domain_scores_gemma":[0.9994972,0.0002494291,0.00008443298,0.00008477872,0.00004865873,0.00003552817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007684235,0.0001791801,0.01970577,0.0001118545,0.0001099324,0.000001911478,0.001863205,0.00001316679,0.9551065,0.0003763912,0.0002924057,0.02147124],"study_design_scores_gemma":[0.01542431,0.0002215141,0.1722214,0.0001773672,0.0001913009,0.000001260531,0.0002014315,0.002695459,0.7912292,0.00269892,0.01474898,0.0001888359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974841,0.001877578,0.01022974,0.01206148,0.0001777214,0.0006620723,0.00008364615,0.00001100276,0.00005573242],"genre_scores_gemma":[0.9826422,0.0139089,0.001514752,0.000756059,0.00005406037,0.000026124,0.0003143134,0.00001017429,0.0007734109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1638773,"threshold_uncertainty_score":0.2861731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618069703605344,"score_gpt":0.2706883135924937,"score_spread":0.2545076165564403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}