{"id":"W4416702386","doi":"10.1016/j.bbrc.2025.153050","title":"HIF-1α silencing downregulates SLC37A2, SLC37A3, and G6PC3 gene expression and impacts glioblastoma stemness features in 3D neurospheres","year":2025,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Reprogramming; Neurosphere; Gene silencing; Glioblastoma; Phenotype; Mimicry; Gene expression; Vasculogenic mimicry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345923,0.000247456,0.0002697354,0.0002614312,0.0002033909,0.0002703116,0.0001584566,0.0001996061,0.001034639],"category_scores_gemma":[0.00008843236,0.00009781263,0.0003019206,0.0002439205,0.0003007571,0.0001146821,0.0001325092,0.0003672993,0.0003001495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004123676,"about_ca_system_score_gemma":0.0003170418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003116695,"about_ca_topic_score_gemma":0.004205855,"domain_scores_codex":[0.9998629,0.00001125832,0.00001448141,0.00002762048,0.00005175444,0.00003202031],"domain_scores_gemma":[0.9999324,0.000009571855,0.00001788088,0.000007373315,0.00001127829,0.00002138035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007641139,0.00002288178,0.0002987074,0.00004930108,0.000008226711,0.00004137295,0.00003868616,0.0001142968,0.9981439,0.00008276402,0.0001829842,0.0009405482],"study_design_scores_gemma":[0.00001681321,0.0001542523,0.007458266,0.000007554385,0.00002606071,0.0001195479,0.00005709617,0.00167025,0.9868761,0.00004968944,0.003558056,0.000006223421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917666,0.0009158787,0.002810464,0.0001313091,0.00003562424,0.00005127968,0.002295495,0.0002262971,0.001767112],"genre_scores_gemma":[0.9929579,0.0005958235,0.002240106,0.00007748658,0.000007301533,0.0001180936,0.002221182,0.00004349668,0.001738618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003116695,"threshold_uncertainty_score":0.006197095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01925944831917449,"score_gpt":0.3315254724130573,"score_spread":0.3122660240938828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}