{"id":"W4416705587","doi":"10.1055/s-0043-1777199","title":"A Phase 1 Study to Assess the Effect of Food on the Pharmacokinetics (PK) and Gastrointestinal (GI) Tolerability of Selumetinib in Adolescents with Neurofibromatosis Type 1 (NF1)-Related Plexiform Neurofibromas (PN)","year":2023,"lang":"en","type":"article","venue":"Neuropediatrics","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Neurofibromatosis; Selumetinib; Tolerability; Pharmacokinetics; Neurofibromatosis type I","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009063021,0.0004008338,0.000699965,0.0003568126,0.00010442,0.00003827807,0.0003318981,0.00003841969,0.000007797324],"category_scores_gemma":[0.001312429,0.0002201314,0.0001106259,0.002981446,0.0001551753,0.00006525006,0.0002672765,0.000571161,0.00001357937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001793505,"about_ca_system_score_gemma":0.00008127495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001814897,"about_ca_topic_score_gemma":0.000002901962,"domain_scores_codex":[0.9964442,0.0009037305,0.0008138248,0.0005892189,0.0008090228,0.0004399911],"domain_scores_gemma":[0.9973119,0.001213798,0.0003225069,0.0007628007,0.0001834837,0.0002054948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005476215,0.002120066,0.9674726,0.0007233277,0.00003930342,0.0004671958,0.0003530736,0.0002216169,0.02217703,0.00001990904,0.0004603213,0.0004693109],"study_design_scores_gemma":[0.01019465,0.1035841,0.8610727,0.0004883853,0.0005052284,0.0004437412,0.0002208839,0.0009727167,0.02219466,0.000006336346,0.00004168605,0.0002748562],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965556,0.00003356004,0.000002428576,0.0003775883,0.0001609059,0.002603883,0.00004371734,0.0000953096,0.0001270061],"genre_scores_gemma":[0.9995767,0.00002651464,0.00002591757,0.0001747287,0.00005666725,0.00003963644,0.000005533521,0.00007792282,0.00001634701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1063999,"threshold_uncertainty_score":0.89767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03744390858489276,"score_gpt":0.3049924599838615,"score_spread":0.2675485513989688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}