{"id":"W4416705587","doi":"10.1055/s-0043-1777199","title":"A Phase 1 Study to Assess the Effect of Food on the Pharmacokinetics (PK) and Gastrointestinal (GI) Tolerability of Selumetinib in Adolescents with Neurofibromatosis Type 1 (NF1)-Related Plexiform Neurofibromas (PN)","year":2023,"lang":"en","type":"article","venue":"Neuropediatrics","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Neurofibromatosis; Selumetinib; Tolerability; Pharmacokinetics; Neurofibromatosis type I","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001146139,0.001073899,0.001773668,0.0002591029,0.0003890757,0.0007831581,0.0005326401,0.001171766,0.003466546],"category_scores_gemma":[0.001640597,0.0005371015,0.001523043,0.0002696586,0.0008382693,0.00102174,0.0003074753,0.003144298,0.0006191776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008186665,"about_ca_system_score_gemma":0.001145315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005831595,"about_ca_topic_score_gemma":0.001324665,"domain_scores_codex":[0.9995499,0.000216884,0.00002370736,0.00009961695,0.00004676149,0.00006307594],"domain_scores_gemma":[0.9988895,0.0002951356,0.0002101164,0.0001059417,0.00008260559,0.0004166223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8154057,0.06926101,0.01002836,0.0008167898,0.002192544,0.0004129623,0.0003568406,0.001825872,0.02614317,0.0003009053,0.001856988,0.07139885],"study_design_scores_gemma":[0.2672262,0.7069423,0.01710734,0.0000368358,0.0007479058,0.0004150367,0.00008487675,0.0009750694,0.003370711,0.0002170941,0.002840715,0.00003589304],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995501,0.0009657471,0.0004465279,0.0001988858,0.00008856101,0.001202684,0.0006992953,0.00003855974,0.0008588135],"genre_scores_gemma":[0.9923916,0.0009564204,0.001600946,0.0006843316,0.0001152249,0.00164525,0.001088028,0.00002668778,0.001491463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003466546,"threshold_uncertainty_score":0.01159674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03744390858489276,"score_gpt":0.3049924599838615,"score_spread":0.2675485513989688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}