{"id":"W4416707828","doi":"10.1681/asn.20251rhy72gh","title":"Complement Activation as a Distinctive Biomarker of Pediatric Idiopathic Nephrotic Syndrome: Differentiating FSGS from Minimal Change Disease and Evidence of Podocyte Involvement","year":2025,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Minimal change disease; Podocyte; Biomarker; Complement system; Complement (music); Nephrotic syndrome; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004948918,0.0003640634,0.0003739863,0.0008533644,0.0001913338,0.0004579331,0.0002071753,0.0003422734,0.0008302077],"category_scores_gemma":[0.0008676374,0.0001293108,0.0001885156,0.000579356,0.000386572,0.0003314821,0.0002422017,0.0003200736,0.0001146993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003007666,"about_ca_system_score_gemma":0.0003957889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009374182,"about_ca_topic_score_gemma":0.001338638,"domain_scores_codex":[0.9996499,0.00006403618,0.00005288502,0.00006731098,0.0001049843,0.00006087789],"domain_scores_gemma":[0.9994283,0.0001042308,0.0002301542,0.00001624256,0.00007900557,0.0001419706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001853516,0.00003030697,0.9896165,0.00003027205,0.00001827564,0.0009162739,0.0000626086,0.00007615975,0.006435305,0.0000409448,0.00007487547,0.002512967],"study_design_scores_gemma":[0.000009208776,0.0003146345,0.9881777,0.000021477,0.00003874441,0.007157905,0.0001570186,0.0006090174,0.003073616,0.00005040436,0.0003850049,0.000005296761],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985656,0.0006129194,0.0002277894,0.00002559036,0.00000394735,0.00001591046,0.000077914,0.000008486542,0.0004618676],"genre_scores_gemma":[0.9990726,0.0001802944,0.0005548524,0.00002065459,0.000006705955,0.000009344364,0.0001162581,0.000001907518,0.00003734771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009374182,"threshold_uncertainty_score":0.002777278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04288074518951831,"score_gpt":0.3162489225080115,"score_spread":0.2733681773184932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}