{"id":"W4416716428","doi":"10.1021/acsomega.5c05830","title":"Can Prions Carry Biological Information?","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"","keywords":"Translation (biology); Folding (DSP implementation); Protein folding; Prion protein; Carry (investment); Extension (predicate logic)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006422123,0.00007058281,0.00006173706,0.00003659465,0.00008721778,0.00002752447,0.000143878,0.00009276609,0.000008745205],"category_scores_gemma":[0.0001281208,0.00006111117,0.00005000953,0.00009446109,0.00003330925,0.000003979116,0.0001231805,0.00004810118,0.00001453669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009432142,"about_ca_system_score_gemma":0.0000858984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002034882,"about_ca_topic_score_gemma":0.000008564853,"domain_scores_codex":[0.999577,0.00002046995,0.0001161976,0.0001080917,0.00004406635,0.0001341431],"domain_scores_gemma":[0.9996725,0.000007358881,0.0000275713,0.0002017337,0.00004304064,0.0000477627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000269106,0.0001740605,0.0643205,0.0001171487,0.0003519277,0.000007179451,0.0001979992,0.0001582973,0.4953831,0.02808104,0.1003117,0.3106279],"study_design_scores_gemma":[0.0004132014,0.00007838842,0.018263,0.00001518854,0.00001255372,0.000002649128,0.00007749577,0.00001134712,0.05047695,0.0013342,0.9291497,0.0001652956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903104,0.002644154,0.0006411888,0.001311322,0.0001495453,0.0001647582,0.00004550505,0.00002456398,0.004708609],"genre_scores_gemma":[0.9968202,0.0006459696,0.0001888221,0.001786826,0.00005328165,0.00002839563,0.000155008,0.000002558918,0.0003189235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8288381,"threshold_uncertainty_score":0.2492041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007604849758092434,"score_gpt":0.253397693327323,"score_spread":0.2457928435692305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}