{"id":"W4416716428","doi":"10.1021/acsomega.5c05830","title":"Can Prions Carry Biological Information?","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"","keywords":"Translation (biology); Folding (DSP implementation); Protein folding; Prion protein; Carry (investment); Extension (predicate logic)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003562888,0.0007641427,0.001517097,0.00194474,0.002142823,0.005997194,0.001532261,0.004700531,0.003310194],"category_scores_gemma":[0.01081202,0.0005547698,0.0005683984,0.001264218,0.01370544,0.0159459,0.002419349,0.003302322,0.002665915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007549084,"about_ca_system_score_gemma":0.000912379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008878079,"about_ca_topic_score_gemma":0.0005216664,"domain_scores_codex":[0.998708,0.0004232991,0.00006632151,0.0002258272,0.0004191657,0.0001573557],"domain_scores_gemma":[0.9942586,0.003167773,0.000476049,0.001153094,0.0006400236,0.0003044216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001252142,0.00005898032,0.0013402,0.0009759702,0.00008503054,0.001236711,0.001995614,0.000847415,0.005363011,0.9078618,0.01718283,0.06292722],"study_design_scores_gemma":[0.00001834948,0.00005967863,0.0003956254,0.000217532,0.00003638173,0.0009871393,0.0004542391,0.000752695,0.001990839,0.9166644,0.07837626,0.0000468565],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07918712,0.520061,0.09849351,0.2103599,0.01638459,0.0001373777,0.0005805426,0.0009829453,0.07381304],"genre_scores_gemma":[0.6515656,0.2508357,0.02346987,0.03069139,0.01540006,0.0002185945,0.0005865163,0.0001884032,0.02704393],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005997194,"threshold_uncertainty_score":0.01884258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007604849758092434,"score_gpt":0.253397693327323,"score_spread":0.2457928435692305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}