{"id":"W4416718643","doi":"10.1084/jem.20250711","title":"The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites","year":2025,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Australian Research Council; National Institutes of Health; Australian Nuclear Science and Technology Organisation; Australian Cancer Research Foundation; Australian Synchrotron; Faculty of Medicine, Nursing and Health Sciences, Monash University; Cardiff University","keywords":"Endoplasmic reticulum; ER retention; Cell; Major histocompatibility complex; Plasma protein binding; Binding site; Vitamin; MHC class I","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008834512,0.000254616,0.0001476452,0.00007605133,0.00009199564,0.0001564146,0.0001328795,0.0002058537,0.001082297],"category_scores_gemma":[0.0001004201,0.00005579807,0.0001238469,0.00004303074,0.0001405959,0.0001030349,0.0001328932,0.0002387121,0.0002361653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667718,"about_ca_system_score_gemma":0.00007916061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003705515,"about_ca_topic_score_gemma":0.0003477558,"domain_scores_codex":[0.9999195,0.00001992255,0.000003277874,0.00002070385,0.00001313535,0.00002344948],"domain_scores_gemma":[0.9999499,0.00001006034,0.00001583628,0.000004966089,0.000005930121,0.00001317518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007360021,0.000006010865,0.0001801598,0.00001895313,0.000001501715,0.00001685692,0.000006397916,0.00002383959,0.9988052,0.00002935089,0.00001016707,0.0008280072],"study_design_scores_gemma":[0.0000103327,0.0004657396,0.004658134,0.000004645769,0.000007759776,0.0001916597,0.00002028192,0.0004195736,0.9925159,0.00002336058,0.001679566,0.000003057125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961973,0.001476701,0.001398917,0.00004794036,0.000006367771,0.000009738745,0.00004494047,0.00003143181,0.0007865994],"genre_scores_gemma":[0.9978728,0.0003089442,0.001000524,0.0000262789,0.000003938012,0.000004779389,0.00008063936,0.000004794724,0.0006971408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082297,"threshold_uncertainty_score":0.003620684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009038318600319985,"score_gpt":0.2816709139528905,"score_spread":0.2726325953525705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}