{"id":"W4416719097","doi":"10.1128/mbio.02680-25","title":"Compartmentalized cell envelope biosynthesis in <i>Mycobacterium tuberculosis</i>","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Compartmentalization (fire protection); Membrane protein; Glycolipid; Membrane; Enzyme; Cell membrane; Protein domain; Membrane lipids; Biosynthesis; Cell fractionation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003986237,0.0001605585,0.0004963626,0.0002816049,0.00004915134,0.00001430826,0.000122659,0.0001344164,0.0005017007],"category_scores_gemma":[0.0002168228,0.0001346719,0.0001217427,0.0004246176,0.00009548145,0.00004685814,0.00009655458,0.0002357148,0.0003579682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001741271,"about_ca_system_score_gemma":0.0001068225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004255449,"about_ca_topic_score_gemma":0.0001356812,"domain_scores_codex":[0.9984909,0.0001829831,0.0003651288,0.0003349922,0.0001364658,0.0004894838],"domain_scores_gemma":[0.9991995,0.0002323138,0.00003246694,0.000345372,0.00003745323,0.0001529086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006396868,0.0007976762,0.727104,0.0003198773,0.0001427792,0.00009857201,0.0001067633,0.000002155319,0.1553957,0.0004721257,0.1102632,0.004657561],"study_design_scores_gemma":[0.003339829,0.0001656064,0.5877351,0.0002040173,0.00008215616,0.00001969787,0.0001298967,0.000182107,0.1470713,0.0002305138,0.260621,0.0002187955],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9150661,0.0008890579,0.0000226215,0.01609535,0.0001949904,0.0004401318,0.00001803953,0.00006858265,0.06720509],"genre_scores_gemma":[0.9903785,0.0005486802,0.0005671636,0.00588925,0.00004617481,0.00006191557,0.0000636199,0.00001288438,0.002431839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1503578,"threshold_uncertainty_score":0.5493271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784800473832786,"score_gpt":0.3093844948067362,"score_spread":0.2915364900684083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}