{"id":"W4416723335","doi":"10.1242/dev.204910","title":"Epigenomic alterations and neural development anomalies in induced pluripotent stem cells from sporadic Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; Hospital for Sick Children; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Induced pluripotent stem cell; Epigenomics; Reprogramming; Epigenome; DNA methylation; Neural stem cell; Forebrain; Somatic cell; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774858,0.0002393874,0.0001980873,0.0001870839,0.0001709996,0.00006814571,0.0002335493,0.00009669234,0.00001640795],"category_scores_gemma":[0.000007752244,0.0002437637,0.00003410059,0.0001456654,0.00004876007,0.000008535566,0.0003625845,0.0001204137,0.00002252153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001053572,"about_ca_system_score_gemma":0.000764782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004694796,"about_ca_topic_score_gemma":0.0002812414,"domain_scores_codex":[0.9983032,0.00008282283,0.0004402592,0.0005890406,0.0002019739,0.0003826781],"domain_scores_gemma":[0.9993955,0.00001903081,0.00006114629,0.0002863967,0.00004967799,0.0001882025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004190246,0.0004446958,0.1225761,0.0001038869,0.0005745491,0.0001480853,0.001469052,0.000531279,0.73813,0.00007001661,0.0008383825,0.134695],"study_design_scores_gemma":[0.0009726111,0.00002988949,0.3305977,0.00007425932,0.00002301744,0.000001442203,0.0001986402,0.0004160998,0.634631,0.000024419,0.03262052,0.0004104284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953856,0.003097696,0.0003573039,0.000291238,0.0001991902,0.0005043683,0.00001636067,0.000014877,0.0001333616],"genre_scores_gemma":[0.9963546,0.0001311731,0.00220778,0.0002449089,0.00003292665,0.0001384356,0.0002366657,0.00001888856,0.0006345584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2080216,"threshold_uncertainty_score":0.9940396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02142663904935632,"score_gpt":0.2564268041635378,"score_spread":0.2350001651141815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}