{"id":"W4416723335","doi":"10.1242/dev.204910","title":"Epigenomic alterations and neural development anomalies in induced pluripotent stem cells from sporadic Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; Hospital for Sick Children; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Induced pluripotent stem cell; Epigenomics; Reprogramming; Epigenome; DNA methylation; Neural stem cell; Forebrain; Somatic cell; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007796755,0.0002303933,0.0001101644,0.0002874882,0.00009306292,0.0001681035,0.00007754994,0.0001497606,0.0007634763],"category_scores_gemma":[0.0001275413,0.00009037031,0.0001392239,0.0001292769,0.0001421247,0.0001243494,0.0001664962,0.0002273052,0.0001565645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009799469,"about_ca_system_score_gemma":0.0001090953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003308339,"about_ca_topic_score_gemma":0.0006997078,"domain_scores_codex":[0.999945,0.000007089369,0.000007780165,0.00001371423,0.00001769869,0.000008730673],"domain_scores_gemma":[0.9999571,0.000006733189,0.00001515025,0.000007050194,0.000005675746,0.000008314093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004949523,0.000006996751,0.001850476,0.00002411869,0.000009399072,0.0002530185,0.0000338813,0.00004839591,0.9944851,0.0001038646,0.00002395845,0.00311133],"study_design_scores_gemma":[0.00001178374,0.0002161957,0.1427487,0.00001457125,0.00008545132,0.005654781,0.0001196233,0.0007380917,0.8453155,0.0005644771,0.004522391,0.000008567829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932923,0.001420688,0.003581041,0.00004369037,0.00001273934,0.00001292717,0.0004015229,0.00006343316,0.001171519],"genre_scores_gemma":[0.9963139,0.0008602331,0.001068698,0.00003265794,0.000005449613,0.00001495635,0.00072041,0.00001082416,0.0009728763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007634763,"threshold_uncertainty_score":0.002554059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02142663904935632,"score_gpt":0.2564268041635378,"score_spread":0.2350001651141815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}