{"id":"W4416733839","doi":"10.1093/infdis/jiaf600","title":"Safety and Immunogenicity of a <i>Klebsiella pneumoniae</i> Tetravalent Bioconjugate Vaccine (Kleb4V) Administered to Healthy Adults: A First-in-Human Phase I/II Randomized and Controlled Study","year":2025,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Immunogenicity; Bioconjugation; Population; Conjugate; Conjugate vaccine; Antibody response; Vaccination; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002805998,0.001252617,0.002076658,0.0002866113,0.0003916544,0.0009749542,0.0009299071,0.001991383,0.003269099],"category_scores_gemma":[0.002030578,0.0007400397,0.001633679,0.0003940469,0.001219648,0.0008485969,0.0003495349,0.001896121,0.0005557339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000771905,"about_ca_system_score_gemma":0.001269965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006588202,"about_ca_topic_score_gemma":0.0009775567,"domain_scores_codex":[0.9986613,0.0007402726,0.0001245254,0.0002168252,0.0001326235,0.0001244775],"domain_scores_gemma":[0.9980546,0.0004305693,0.0008520866,0.0001213661,0.0001960534,0.0003452848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9620076,0.01230723,0.001169039,0.001046217,0.001063203,0.00003259748,0.0000503144,0.0001736682,0.009438118,0.00003396423,0.0003428012,0.01233535],"study_design_scores_gemma":[0.6216993,0.3706879,0.003319824,0.00006708402,0.001189198,0.00005294615,0.00002616986,0.0002117167,0.00207223,0.0000568051,0.0006015349,0.00001524981],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923522,0.003263513,0.0005267751,0.000256933,0.0001901904,0.002336381,0.0004801193,0.00004115945,0.0005526862],"genre_scores_gemma":[0.9907874,0.002632041,0.001304337,0.0006765331,0.0002991108,0.002596229,0.0007075235,0.00001839044,0.0009784821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003269099,"threshold_uncertainty_score":0.01483971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003866655315172017,"score_gpt":0.2762858649026302,"score_spread":0.2724192095874582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}