{"id":"W4416738208","doi":"10.1016/j.immuni.2025.10.014","title":"Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients","year":2025,"lang":"en","type":"article","venue":"Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emmanuel Bible College","funders":"Argonne National Laboratory; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Universitat Autònoma de Barcelona; Georgia Research Alliance","keywords":"Antibody; B cell; Epitope; Immunodominance; HLA-B; Antigen; Human leukocyte antigen; T cell; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140748,0.0001087366,0.0001760109,0.0001518595,0.0001122069,0.0002063078,0.00009348363,0.0001313465,0.0005948387],"category_scores_gemma":[0.0002217997,0.0000916524,0.00009750736,0.00006758812,0.0001617616,0.0001157356,0.0002032674,0.0002641635,0.0001598476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008973486,"about_ca_system_score_gemma":0.00007920169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543824,"about_ca_topic_score_gemma":0.0001531794,"domain_scores_codex":[0.999896,0.00002229059,0.000008744545,0.00001892498,0.00002422861,0.00002978794],"domain_scores_gemma":[0.9998921,0.00001545418,0.00003059367,0.00001094861,0.000008464403,0.00004235727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002108265,0.00003387473,0.00663424,0.00000853412,0.000005103046,0.0001011729,0.00003339806,0.00008083368,0.9918678,0.00004229059,0.000008610311,0.0009732298],"study_design_scores_gemma":[0.00005564635,0.003352079,0.5379417,0.00001058255,0.00006859046,0.003950513,0.0005022147,0.003015116,0.4501273,0.0001915709,0.0007677348,0.00001702224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997817,0.00003604575,0.00009087171,0.000002777112,7.045197e-7,9.045486e-7,0.000003375286,0.000002258784,0.00008134912],"genre_scores_gemma":[0.9998636,0.00002283032,0.00004203025,0.000006100689,0.000001332207,0.000001215933,0.00001004658,0.000001265809,0.00005151516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005948387,"threshold_uncertainty_score":0.001989901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00788778035156652,"score_gpt":0.2322835767435918,"score_spread":0.2243957963920253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}