{"id":"W4416745706","doi":"10.1021/acsomega.5c08336","title":"Compounds Reducing Human Sperm Motility as Potential Nonhormonal Contraceptives Identified Using a High-Throughput Phenotypic Screening Platform","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Medicines for Malaria Venture; Scottish Funding Council; National Physical Science Consortium; Bill and Melinda Gates Foundation","keywords":"Phenotype; Motility; Phenotypic screening; Male contraceptive; Sperm motility; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083007,0.0006175928,0.0005887729,0.0007845687,0.000244702,0.0005466919,0.0004113874,0.000269481,0.002934603],"category_scores_gemma":[0.0002886838,0.0001768839,0.0005731275,0.0005017013,0.0002416253,0.0003477399,0.0003052977,0.0005738424,0.0007674712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002584501,"about_ca_system_score_gemma":0.0003748798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003971493,"about_ca_topic_score_gemma":0.001521098,"domain_scores_codex":[0.9998109,0.00004114241,0.00001283018,0.00002994593,0.00007871372,0.00002651745],"domain_scores_gemma":[0.9998494,0.00003475145,0.00002955306,0.0000201784,0.0000455545,0.00002052625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002836358,0.0002815461,0.001350317,0.001014441,0.0000946775,0.0004793267,0.00006791003,0.001913131,0.9218896,0.000562563,0.001018975,0.07104386],"study_design_scores_gemma":[0.0001451201,0.006207966,0.008401541,0.0001010636,0.0003604968,0.00151137,0.0001416817,0.002242628,0.9449824,0.0003743552,0.03546027,0.00007116677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8680508,0.05384662,0.0513475,0.001441845,0.0003065751,0.001577425,0.004247289,0.001339897,0.0178421],"genre_scores_gemma":[0.9006519,0.04915801,0.03204291,0.0006875932,0.0001517076,0.0004131587,0.003835432,0.0001093591,0.01295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002934603,"threshold_uncertainty_score":0.009817243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0317368712202046,"score_gpt":0.3306232492122216,"score_spread":0.2988863779920171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}