{"id":"W4416746955","doi":"10.1038/s41598-025-26517-9","title":"Human MAdCAM-1 antibodies as targeted immune modulators","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Lamina propria; Antibody; Immune system; Inflammation; Antigen; Gastrointestinal tract; Cell adhesion molecule; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174704,0.0003695567,0.000238836,0.00027655,0.00008838834,0.0002997195,0.000281001,0.0003748262,0.001696227],"category_scores_gemma":[0.0001586326,0.0001047944,0.0001677097,0.0001734962,0.0001082395,0.0001479204,0.0001622663,0.0004612375,0.0003427205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003554274,"about_ca_system_score_gemma":0.000133893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003326258,"about_ca_topic_score_gemma":0.0005385045,"domain_scores_codex":[0.9998637,0.00003830331,0.00000611299,0.00002206511,0.0000303721,0.00003939846],"domain_scores_gemma":[0.9999555,0.00001397369,0.000008770304,0.000003743256,0.000007838735,0.00001004054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003020739,0.0001700601,0.0004426359,0.0001804199,0.0000230299,0.00009933667,0.00002648681,0.0004026043,0.9726051,0.0005857196,0.0004612908,0.02470127],"study_design_scores_gemma":[0.000342346,0.003518253,0.004953773,0.00006828658,0.0000994916,0.001135768,0.00002619334,0.002599054,0.9377675,0.0002757808,0.04920109,0.00001246895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.939051,0.04122943,0.01020299,0.0003524849,0.0002150286,0.000250695,0.0003710481,0.0002084943,0.008118809],"genre_scores_gemma":[0.9810243,0.008738359,0.005854944,0.0002639538,0.00006112511,0.0001209155,0.0005578707,0.00001246635,0.003366117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696227,"threshold_uncertainty_score":0.005674422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618650946799061,"score_gpt":0.3326857960253065,"score_spread":0.3164992865573159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}