{"id":"W4416753414","doi":"10.1101/2025.11.25.25339898","title":"Charting Brain Structure in 22q11.2 Deletion Syndrome with Clinical Neuroimaging","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"National Institute of Mental Health","keywords":"Neuroimaging; Cognition; Brain Structure and Function; Imaging genetics; Deletion syndrome; Brain morphometry; Value (mathematics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001312962,0.0003590613,0.0001619809,0.002109566,0.0001873412,0.000521512,0.0004264757,0.0002810824,0.0005669649],"category_scores_gemma":[0.006063916,0.0001465176,0.0001752219,0.001071847,0.0005948217,0.000284201,0.0006059994,0.0002340999,0.00009792266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005373747,"about_ca_system_score_gemma":0.0003493433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007902501,"about_ca_topic_score_gemma":0.01086029,"domain_scores_codex":[0.9994661,0.0001696598,0.0000509011,0.0001193596,0.0001589381,0.0000350703],"domain_scores_gemma":[0.9976046,0.0008741237,0.0007914006,0.0002454019,0.0003954832,0.00008890902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002190929,0.00002016696,0.9703333,0.00004057004,0.00008597363,0.001068773,0.0005586027,0.004625448,0.007184616,0.0004913705,0.0004535301,0.01491851],"study_design_scores_gemma":[0.00001074106,0.00009042722,0.9808663,0.00001711866,0.00004014046,0.004215311,0.0002610206,0.008646744,0.004266631,0.0006731562,0.0008937576,0.00001863528],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959163,0.0001579179,0.002970496,0.00003000612,0.00000266039,0.0000196639,0.0004362346,0.00004034162,0.0004264114],"genre_scores_gemma":[0.9955679,0.00006824645,0.003718193,0.000007546722,0.000002676856,0.00002223084,0.000542235,0.00001382983,0.00005721253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007902501,"threshold_uncertainty_score":0.01571304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02371006831643062,"score_gpt":0.3505610338784066,"score_spread":0.326850965561976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}