{"id":"W4416754171","doi":"10.1101/2025.11.24.690170","title":"NLRP1 Shapes Immune and Inflammatory Signatures in Human Melanoma but Not in Mouse Models","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Melanoma; Pyroptosis; Immune system; Inflammasome; NLRP1; AIM2; Function (biology); Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004042845,0.0003972581,0.0003206035,0.0007696269,0.0001294712,0.000468928,0.00008434398,0.0003386358,0.001943201],"category_scores_gemma":[0.000242644,0.0001676483,0.0002980752,0.000326673,0.0002609126,0.0002341559,0.0002451487,0.0007116144,0.0006482737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201437,"about_ca_system_score_gemma":0.0001080649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002352816,"about_ca_topic_score_gemma":0.0002358208,"domain_scores_codex":[0.9996829,0.00007824929,0.00002097708,0.0001058951,0.00006739851,0.00004458824],"domain_scores_gemma":[0.9997781,0.00002904823,0.00008481623,0.00004911053,0.00001866114,0.00004023151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007108719,0.00007864594,0.002673942,0.00004279095,0.00002082867,0.0001019906,0.00003702751,0.0001153741,0.9928999,0.0001236057,0.0001578828,0.003037063],"study_design_scores_gemma":[0.0001756053,0.002398707,0.1031281,0.00006281986,0.0001870905,0.004633464,0.0002554988,0.00378031,0.8710487,0.0009532759,0.01334455,0.00003176726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872798,0.002725044,0.006451417,0.0002000596,0.00006087223,0.00007692806,0.001118461,0.0002301384,0.001857318],"genre_scores_gemma":[0.994672,0.000718615,0.001820233,0.00009200745,0.00001193693,0.00004853453,0.0006700123,0.0000646537,0.001901922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001943201,"threshold_uncertainty_score":0.006500661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007492828765020498,"score_gpt":0.2097246004616961,"score_spread":0.2022317716966756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}