{"id":"W4416754951","doi":"10.1101/2025.11.26.690702","title":"Homotypic endoplasmic reticulum membrane tethering is critical for flavivirus replication","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Emory College of Arts and Sciences, Emory University; School of Medicine, Emory University; National Institutes of Health; Emory University","keywords":"Flavivirus; Endoplasmic reticulum; Biogenesis; Viral replication; Organelle; Organelle biogenesis; Dengue virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223946,0.0003361612,0.0001632891,0.0001567888,0.0003689396,0.0006267127,0.0001907984,0.0004575686,0.001392359],"category_scores_gemma":[0.0001342783,0.000151726,0.0002842991,0.0001223985,0.0001741465,0.0004852893,0.0005099647,0.0003833621,0.0007941444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000338566,"about_ca_system_score_gemma":0.0001695863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005801324,"about_ca_topic_score_gemma":0.0008772706,"domain_scores_codex":[0.9998318,0.00001506274,0.00001571096,0.00005232938,0.00004570818,0.00003940702],"domain_scores_gemma":[0.999884,0.00000737601,0.00004972997,0.00001353748,0.00001674785,0.00002857948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003477574,0.000008213953,0.0005192138,0.00003854565,0.000003802484,0.00008471859,0.00001296752,0.00003169179,0.9977562,0.0000922652,0.00004768849,0.001369973],"study_design_scores_gemma":[0.00002284837,0.0002927865,0.0678015,0.00002484262,0.00003513506,0.001881313,0.0001718221,0.00203451,0.9121107,0.0003169244,0.01528985,0.00001773784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864806,0.005442799,0.004995369,0.0001442588,0.00006149574,0.00003222977,0.0005100943,0.0002236757,0.002109511],"genre_scores_gemma":[0.994372,0.0007609164,0.00190554,0.00004242301,0.00001211802,0.00001149044,0.0005584566,0.00001593189,0.002321179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392359,"threshold_uncertainty_score":0.004657924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491914552273146,"score_gpt":0.2752840460283257,"score_spread":0.2603649005055942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}