{"id":"W4416757388","doi":"10.1093/braincomms/fcaf467","title":"Inflammation PET and plasma neurofilament light predict survival in people with progressive supranuclear palsy","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; Cardio-Pulmonary Institute; Dementias Platform UK; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Progressive Supranuclear Palsy Association; Wellcome Trust; Alzheimer's Society; Cambridge Trust; Center for Research on Violence Against Women, University of Kentucky; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Medical Research Council Canada; Sidney Sussex College, University of Cambridge; UK Dementia Research Institute; Vetenskapsrådet; University of Cambridge; Department of Health and Social Care","keywords":"Progressive supranuclear palsy; Atrophy; Biomarker; Cohort; Neuroinflammation; Temporal lobe; Neurodegeneration; Tauopathy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001372461,0.0001181683,0.0001913627,0.0001458508,0.0001538417,0.00003356704,0.0001585043,0.00003252371,0.00002117775],"category_scores_gemma":[0.00009301482,0.00009842239,0.0000267166,0.0002948055,0.00006212201,0.00008026842,0.0001605231,0.0001401819,0.000008655886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006190074,"about_ca_system_score_gemma":0.0001293638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005570937,"about_ca_topic_score_gemma":0.0005659589,"domain_scores_codex":[0.9991991,0.00014404,0.0001875483,0.0001883328,0.0001385651,0.0001424068],"domain_scores_gemma":[0.9988028,0.0001953422,0.00006676611,0.0007949081,0.00006155701,0.00007860983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001596282,0.003312167,0.87984,0.0005131653,0.0008300442,0.0002728501,0.004297586,0.00003983098,0.004161758,0.05698024,0.002314765,0.04584132],"study_design_scores_gemma":[0.005363471,0.0003316173,0.936665,0.0005231935,0.0001953609,0.00004903855,0.0007009117,0.005279532,0.0006110116,0.0004240898,0.04969933,0.0001574487],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647272,0.0004997508,0.00004418161,0.02691376,0.00003176117,0.0008797969,0.00002144588,0.00006880259,0.006813325],"genre_scores_gemma":[0.9966798,0.0002803381,0.001909753,0.0002305194,0.00001072763,0.0002529398,0.0001402735,0.00001375997,0.0004818457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.056825,"threshold_uncertainty_score":0.4013548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133069938568516,"score_gpt":0.27665786436337,"score_spread":0.2633508705065185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}