{"id":"W4416757605","doi":"10.1016/j.jaad.2025.11.070","title":"Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial","year":2025,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Red Deer Regional Hospital; Red Deer Polytechnic","funders":"Sun Pharma; Concert Pharmaceuticals","keywords":"Randomized controlled trial; Safety profile; Janus kinase inhibitor; Janus kinase; Clinical trial; Phases of clinical research; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002194338,0.0008351965,0.001836221,0.0002273011,0.0003738941,0.0008434638,0.0005299084,0.001168619,0.003558994],"category_scores_gemma":[0.001653971,0.0003285552,0.001678788,0.000266581,0.0005851533,0.000695709,0.0002181832,0.001716147,0.0005065857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004654284,"about_ca_system_score_gemma":0.0006414357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004174037,"about_ca_topic_score_gemma":0.001273533,"domain_scores_codex":[0.9993147,0.0003709329,0.00007171399,0.0001069573,0.0000682609,0.000067513],"domain_scores_gemma":[0.9987558,0.0003571477,0.0004432509,0.0000590895,0.00008975014,0.0002948935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.920709,0.006934224,0.006166988,0.002063133,0.003187955,0.0001237275,0.0001363741,0.000510125,0.007981566,0.0001546515,0.003022571,0.04900965],"study_design_scores_gemma":[0.9106157,0.07149629,0.01359185,0.00009978366,0.001393492,0.0001805645,0.00003450359,0.0004871996,0.0007002423,0.0001283592,0.001253647,0.00001835823],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738322,0.01946425,0.0003676071,0.0009089002,0.0002405589,0.001362451,0.001378839,0.00007845523,0.002366688],"genre_scores_gemma":[0.9912484,0.003988609,0.0006062327,0.0009953048,0.0003643013,0.0009333653,0.001151302,0.00001064354,0.0007018881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003558994,"threshold_uncertainty_score":0.01190603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673547740199586,"score_gpt":0.3291126137284758,"score_spread":0.3123771363264799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}