{"id":"W4416757667","doi":"10.1016/j.ejps.2025.107388","title":"Nortriptyline-targeted siRNA-loaded liposomes: Design, affinity, biodistribution, and bioactivity in a murine Herpes Simplex Virus 1 corneal infection model","year":2025,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; National Institute of Dental and Craniofacial Research; Canada Foundation for Innovation; Israel Science Foundation; Hebrew University of Jerusalem; Fraunhofer-Gesellschaft; Canadian Cancer Society","keywords":"Herpes simplex virus; Liposome; Keratitis; Trigeminal ganglion; Drug delivery; Biodistribution; Virus; Cell culture; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000182636,0.0003479016,0.0002336938,0.0001807159,0.00009660749,0.0002336347,0.0002426661,0.0002661448,0.0002813994],"category_scores_gemma":[0.0001013878,0.0001591752,0.00017657,0.0001060873,0.0001470174,0.0002310361,0.0001410908,0.0002507092,0.000203077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004013894,"about_ca_system_score_gemma":0.0001992498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001334043,"about_ca_topic_score_gemma":0.00126866,"domain_scores_codex":[0.9999156,0.00001293235,0.00000923545,0.00002315693,0.00002048507,0.00001862778],"domain_scores_gemma":[0.9999467,0.000007109299,0.00001680297,0.000003971506,0.00001385519,0.00001157383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000100052,0.00001821065,0.00006923281,0.00003638084,0.000003156784,0.00001800869,0.00001614892,0.0001016618,0.9984655,0.00003470603,0.00001569394,0.001121119],"study_design_scores_gemma":[0.00001440032,0.000349003,0.0007924076,0.000002515422,0.00002106689,0.00006145839,0.000008969059,0.001254827,0.9968314,0.000009681943,0.0006495065,0.000004830961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901249,0.002024074,0.006581368,0.0000719276,0.00001331626,0.0001290386,0.0002494644,0.00007439038,0.0007314643],"genre_scores_gemma":[0.9895331,0.001670665,0.006501493,0.00004174144,0.000006366761,0.0001153011,0.0003465598,0.00002484265,0.001760022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334043,"threshold_uncertainty_score":0.002912343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09052199770810727,"score_gpt":0.3769940342179263,"score_spread":0.286472036509819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}