{"id":"W4416759013","doi":"10.1016/j.brs.2025.102994","title":"Open letter on intervention regimes and adverse events in focused ultrasound for neuromodulation","year":2025,"lang":"en","type":"letter","venue":"Brain stimulation","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Sunnybrook Health Science Centre","funders":"","keywords":"Neuromodulation; Focused ultrasound; Adverse effect; Intervention (counseling); Psychological intervention","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001679973,0.000243729,0.0002510884,0.0002770439,0.00007298638,0.00004467573,0.0002128255,0.0003629643,0.00002369592],"category_scores_gemma":[0.0001152586,0.0002692752,0.00008303536,0.0001646494,0.00001506217,0.0002304155,0.00003156921,0.0003788147,0.000009959381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001119196,"about_ca_system_score_gemma":0.00001280972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003474092,"about_ca_topic_score_gemma":0.00003541677,"domain_scores_codex":[0.9988952,0.00006400279,0.000343669,0.0003726694,0.0001276291,0.0001968222],"domain_scores_gemma":[0.9987549,0.0008222535,0.00008442518,0.00028433,0.00003409134,0.00002006243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007286969,0.00006988238,0.001273675,0.0005760214,0.00009040481,0.000003632574,0.0002293253,0.05124764,0.001205337,0.0003545452,0.9317873,0.01308937],"study_design_scores_gemma":[0.003466529,0.0001337144,0.04210107,0.0007038941,0.00009282491,0.000003934197,0.000009202161,0.06197153,0.0001229406,0.006640727,0.8840856,0.0006680483],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2395594,0.0002061329,0.1352759,0.5977196,0.002370783,0.01578144,0.0006982859,0.0009824468,0.007405926],"genre_scores_gemma":[0.7408527,0.00003174466,0.003144298,0.2359685,0.002109678,0.001637981,0.007108057,0.0002304392,0.008916658],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5012932,"threshold_uncertainty_score":0.9999759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098118964189806,"score_gpt":0.2709432822189589,"score_spread":0.2499620925770609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}