{"id":"W4416771733","doi":"10.1186/s12974-025-03619-9","title":"Granzyme B contributes to subretinal fibrosis in neovascular age-related macular degeneration by modulating inflammation and epithelial-mesenchymal transition","year":2025,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; Vancouver Coastal Health Research Institute; Vancouver Coastal Health; University of British Columbia Hospital; Vancouver General Hospital; Willow Biosciences (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Foundation Fighting Blindness","keywords":"Fibrosis; Macular degeneration; Granzyme B; Inflammation; Choroidal neovascularization; Angiogenesis; Decorin; Neovascularization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002371064,0.0003833272,0.000288055,0.0003230353,0.0001554379,0.0003425115,0.000173741,0.0004001361,0.001672046],"category_scores_gemma":[0.0001835616,0.0001459056,0.0003303133,0.0001313171,0.0002801185,0.0003276377,0.0003272737,0.0006121236,0.0003844198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002018569,"about_ca_system_score_gemma":0.0001152107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001879011,"about_ca_topic_score_gemma":0.0001858936,"domain_scores_codex":[0.9998676,0.00003195829,0.00001823841,0.00002820358,0.00002510694,0.00002883509],"domain_scores_gemma":[0.9998264,0.00001306169,0.00008739238,0.00001697584,0.0000186714,0.0000375804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009168594,0.0001119153,0.004083372,0.0001572608,0.00003081518,0.0005138724,0.00005916867,0.00005476321,0.9877641,0.0001913306,0.0001311138,0.005985495],"study_design_scores_gemma":[0.0004856453,0.003254294,0.2562189,0.0001364881,0.0003379043,0.01066236,0.0006166175,0.002630995,0.7100248,0.001639933,0.01395405,0.00003798876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861756,0.009825922,0.002189555,0.000269206,0.0000443553,0.00004824494,0.0001877501,0.00009280814,0.001166583],"genre_scores_gemma":[0.9947121,0.002406921,0.001082255,0.0001120653,0.00002239403,0.00003743494,0.0001220368,0.00001245126,0.001492274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672046,"threshold_uncertainty_score":0.005593598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004942038836196297,"score_gpt":0.2433033456532286,"score_spread":0.2383613068170323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}