{"id":"W4416773146","doi":"10.1002/advs.202514056","title":"Mapping Charge Interactions in Intrinsically Disordered Proteins","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE Framework Programme; SCIEX; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Intrinsically disordered proteins; Electrostatics; Charge (physics); Sequence (biology); Conformational ensembles; Dipole; Static electricity; Function (biology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157843,0.00007544286,0.00007161409,0.0001250683,0.0001126967,0.00002208044,0.0002711878,0.0000254517,0.000004515815],"category_scores_gemma":[0.0002515831,0.00007151366,0.00002319292,0.0006142259,0.0001716614,0.00001514076,0.0001605619,0.00009417698,0.000003681775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002944223,"about_ca_system_score_gemma":0.0001534147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001114108,"about_ca_topic_score_gemma":0.0001489977,"domain_scores_codex":[0.9992516,0.00001112259,0.0001270543,0.000313037,0.00008288192,0.0002143017],"domain_scores_gemma":[0.9996148,0.000006079892,0.00003330674,0.0002536354,0.00005835988,0.00003381415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001727685,0.00002072303,0.002045467,0.000005999735,0.000002080752,9.00018e-7,0.00003970477,0.0001142813,0.9707375,0.00247489,0.00001286187,0.02452837],"study_design_scores_gemma":[0.001416742,0.0001473752,0.070892,0.0001579945,0.000003770617,0.00001105397,0.0003407958,0.002104203,0.838276,0.01063041,0.07551511,0.0005045204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944943,0.0001684183,0.04591683,0.0004393564,0.0002419458,0.000311948,0.000003534255,0.00001483735,0.007960157],"genre_scores_gemma":[0.9920319,0.00003328287,0.006773119,0.0002834879,0.00002029176,0.00004912425,0.000006192327,0.000003400743,0.0007991535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1324614,"threshold_uncertainty_score":0.2916242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005134079888718114,"score_gpt":0.2761694480995038,"score_spread":0.2710353682107857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}