{"id":"W4416773146","doi":"10.1002/advs.202514056","title":"Mapping Charge Interactions in Intrinsically Disordered Proteins","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE Framework Programme; SCIEX; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Intrinsically disordered proteins; Electrostatics; Charge (physics); Sequence (biology); Conformational ensembles; Dipole; Static electricity; Function (biology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003002185,0.0004406224,0.0003335553,0.0004015777,0.000269986,0.0004197713,0.0004745543,0.0004975968,0.0002400519],"category_scores_gemma":[0.0009405377,0.0002240959,0.000191588,0.0002306826,0.0005431036,0.0008075359,0.0002732247,0.0003386425,0.00007129055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007503626,"about_ca_system_score_gemma":0.0004387209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003059676,"about_ca_topic_score_gemma":0.002081858,"domain_scores_codex":[0.9999225,0.00001958484,0.000004043904,0.0000190228,0.00002360518,0.00001121033],"domain_scores_gemma":[0.9997448,0.0001476653,0.00004706408,0.00001869229,0.000021206,0.00002048321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002776529,0.00002628309,0.001401556,0.00002844629,0.00001223826,0.00008659258,0.00004203079,0.9463732,0.0439935,0.005228709,0.00004410758,0.002735457],"study_design_scores_gemma":[0.000003042886,0.00001565935,0.0003805929,0.000002047487,0.000001832342,0.00001751601,0.000008056593,0.990818,0.006195713,0.00244183,0.0001110747,0.000004701782],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8658699,0.0004470152,0.1320165,0.00009680502,0.000006675839,0.0000165727,0.00008609573,0.000196921,0.001263439],"genre_scores_gemma":[0.9898226,0.0002946942,0.009466847,0.00001161424,0.000002888198,0.0000128743,0.00005255218,0.00002024589,0.0003155889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003059676,"threshold_uncertainty_score":0.006083727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005134079888718114,"score_gpt":0.2761694480995038,"score_spread":0.2710353682107857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}