{"id":"W4416773282","doi":"10.1111/jdv.70166","title":"Apremilast in Japanese patients with palmoplantar pustulosis: A randomized, Phase 3 trial","year":2025,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Amgen","keywords":"Apremilast; Palmoplantar pustulosis; Phase (matter); MEDLINE; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002143445,0.001129241,0.00224115,0.0002851542,0.0005660734,0.0008215953,0.0005303424,0.001251772,0.00470529],"category_scores_gemma":[0.001322364,0.0005659644,0.001888533,0.0004057422,0.0007458428,0.0006187768,0.0002881193,0.001670337,0.0006194214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005181168,"about_ca_system_score_gemma":0.001566232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008585525,"about_ca_topic_score_gemma":0.002724623,"domain_scores_codex":[0.9995035,0.0002797381,0.00003794747,0.00006677401,0.00004592143,0.00006616616],"domain_scores_gemma":[0.9994111,0.0001201984,0.0001807275,0.00004150896,0.00005497324,0.0001915314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9502568,0.006756185,0.00172752,0.00248621,0.00192495,0.0001688678,0.0001497149,0.0002958851,0.005975821,0.0001522627,0.002204393,0.02790122],"study_design_scores_gemma":[0.9537681,0.04133522,0.002846631,0.00005285846,0.0006135145,0.00007768719,0.0000274834,0.0001883468,0.0001787539,0.00006865653,0.0008312445,0.00001160971],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709738,0.01470402,0.0007631118,0.001568365,0.0006369462,0.007185991,0.001151032,0.000157993,0.002858617],"genre_scores_gemma":[0.9766155,0.006973335,0.001954633,0.002409873,0.0005659792,0.008129735,0.0009705626,0.00002262591,0.002357731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00470529,"threshold_uncertainty_score":0.01574075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00941797863843805,"score_gpt":0.2442129468249714,"score_spread":0.2347949681865333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}