{"id":"W4416777107","doi":"10.1016/j.molpha.2025.100094","title":"Amiodarone irrecoverably impairs the function of human ether-a-go-go-related gene potassium channels","year":2025,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"hERG; Amiodarone; Patch clamp; Potassium channel; Efflux; Electrophysiology; In vitro; Drug","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723193,0.000262494,0.0002977497,0.00008224628,0.0000890907,0.0002087453,0.0001537002,0.000304158,0.0008841163],"category_scores_gemma":[0.0002321399,0.0001107553,0.0002537121,0.00008675622,0.0001283951,0.0002309436,0.0001204324,0.0004034344,0.0002280685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001053642,"about_ca_system_score_gemma":0.0001052867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002323184,"about_ca_topic_score_gemma":0.0002525686,"domain_scores_codex":[0.9998222,0.00003395791,0.00003162667,0.00003291107,0.00003886212,0.00004053013],"domain_scores_gemma":[0.9999121,0.00003013634,0.00001951189,0.00001449703,0.000006106352,0.00001763842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001474067,0.00003155346,0.0001120665,0.00001947552,0.000008021021,0.00007901597,0.000009045572,0.00002131386,0.9987823,0.00002822638,0.00002834982,0.0007332611],"study_design_scores_gemma":[0.00005023194,0.001719507,0.009246177,0.0000053862,0.00003267654,0.0006435902,0.00003179845,0.0009110592,0.9855782,0.00004350011,0.001731973,0.000005831841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996965,0.001567034,0.0006847815,0.00005662544,0.00003664258,0.00001178281,0.0001720945,0.00003500817,0.0004710628],"genre_scores_gemma":[0.9978217,0.0007342162,0.0003609759,0.00004533366,0.00001044629,0.0000170973,0.0003206807,0.000008018075,0.0006814845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008841163,"threshold_uncertainty_score":0.002957642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006870983186066172,"score_gpt":0.284524135099406,"score_spread":0.2776531519133398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}