{"id":"W4416781617","doi":"10.3390/cells14231890","title":"Three-Dimensional Organization of Telomeres: An Emerging Prognostic Biomarker in Multiple Myeloma","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Ontario Genomics","funders":"Canada Research Chairs","keywords":"Multiple myeloma; Telomere; Monoclonal gammopathy of undetermined significance; Disease; Asymptomatic; Bone marrow; Biomarker","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002797254,0.0004897993,0.001833675,0.0008835541,0.00006761524,0.00001709484,0.000270113,0.0004152514,0.000310322],"category_scores_gemma":[0.0006495994,0.0004120656,0.0002279795,0.002085307,0.0001212449,0.00009375366,0.0001230797,0.000364925,0.00007492225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001246211,"about_ca_system_score_gemma":0.000953064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001104927,"about_ca_topic_score_gemma":0.0001080414,"domain_scores_codex":[0.997328,0.0001296203,0.001064944,0.0006758849,0.000402877,0.0003986013],"domain_scores_gemma":[0.9979986,0.0005276835,0.0003834765,0.0006512586,0.0002693852,0.0001696118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002471026,0.0004797772,0.006308683,0.03785636,0.0001327393,0.0001329348,0.0001094218,0.000003409751,0.0006869623,0.00001828911,0.0007382598,0.9535084],"study_design_scores_gemma":[0.003828663,0.0004754073,0.03015978,0.1945128,0.003671569,0.0002246436,0.0002035719,0.001024438,0.002376004,0.00005317765,0.7611243,0.002345596],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005315071,0.9918064,0.0001307476,0.00002371069,0.0005376268,0.001845386,0.00007264708,0.00009696501,0.0001714532],"genre_scores_gemma":[0.003786396,0.9930926,0.00133944,0.00006315426,0.0001059492,0.00004882344,0.0009757207,0.0001096435,0.0004783012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9511629,"threshold_uncertainty_score":0.9998331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04763921343668327,"score_gpt":0.3176648857231548,"score_spread":0.2700256722864715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}