{"id":"W4416782874","doi":"10.1007/s11060-025-05351-z","title":"A phase I-II study of niacin in patients with newly diagnosed glioblastoma: safety and interim phase II analysis","year":2025,"lang":"en","type":"article","venue":"Journal of Neuro-Oncology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Hotchkiss Brain Institute; Ontario Brain Institute; University of Calgary; Alberta Cancer Foundation; Institute of Cancer Research","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"Niacin; Interim analysis; Temozolomide; Toxicity; Refractory (planetary science); Phases of clinical research; Chemotherapy; Univariate analysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001523907,0.001865749,0.003372948,0.0004006349,0.0004732648,0.001285019,0.001001061,0.001327379,0.004095249],"category_scores_gemma":[0.001206379,0.0006557988,0.00257973,0.0004700211,0.001072716,0.001070041,0.0003813131,0.004280389,0.0010732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001173732,"about_ca_system_score_gemma":0.002331532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001527924,"about_ca_topic_score_gemma":0.006504679,"domain_scores_codex":[0.9995878,0.0002062662,0.0000217482,0.00007486751,0.0000346832,0.00007455238],"domain_scores_gemma":[0.9990915,0.0001412634,0.0001896964,0.0001057358,0.00009019421,0.0003816067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8363954,0.02679969,0.005755634,0.002043986,0.006898972,0.0002163935,0.0003295568,0.002821661,0.01889624,0.0004865933,0.00817751,0.09117843],"study_design_scores_gemma":[0.6357202,0.3363,0.0111811,0.0001618792,0.003064229,0.0003800657,0.0001971484,0.001554632,0.003193946,0.0009704432,0.007190793,0.00008535918],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770692,0.00965208,0.001753599,0.001657057,0.0004469759,0.003228688,0.002854407,0.0002446721,0.003093297],"genre_scores_gemma":[0.9719086,0.008221353,0.003553261,0.002397342,0.0002492869,0.003380872,0.004913265,0.0001105593,0.005265561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004095249,"threshold_uncertainty_score":0.01370001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115012897459136,"score_gpt":0.3384764854241372,"score_spread":0.3269751956782236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}