{"id":"W4416789154","doi":"10.1186/s40814-025-01731-4","title":"The SQUEEZE pilot trial: a trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal directed fluid-sparing strategy vs. usual care","year":2025,"lang":"en","type":"article","venue":"Pilot and Feasibility Studies","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster Children's Hospital; Hospital for Sick Children; McMaster University; University of Toronto","funders":"Canadian Institutes of Health Research; Hamilton Health Sciences; Groupe canadien de recherche en soins intensifs; Canadian Child Health Clinician Scientist Program; Canadian Blood Services; McMaster University","keywords":"Septic shock; Randomized controlled trial; Pilot trial; MEDLINE; Early goal-directed therapy; Shock (circulatory)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008536697,0.0003777255,0.00130308,0.000211704,0.000279324,0.00008925925,0.0001239797,0.00006729335,0.00001162284],"category_scores_gemma":[0.002053017,0.0002368081,0.0001739739,0.0004744441,0.0001183898,0.00009138959,0.0001853109,0.0001716743,0.000008612807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376896,"about_ca_system_score_gemma":0.0001182508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009193965,"about_ca_topic_score_gemma":0.003684439,"domain_scores_codex":[0.997141,0.000477863,0.0008153951,0.0007520287,0.0003632909,0.0004504115],"domain_scores_gemma":[0.997689,0.001168468,0.0001038331,0.0004801158,0.0003466425,0.0002119362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6763225,0.001571034,0.3151723,0.0000914878,0.0003003207,0.000004758278,0.003571749,0.000001412883,0.000009492662,0.000009760733,0.0007485618,0.002196681],"study_design_scores_gemma":[0.561585,0.0119149,0.4246955,0.00008217074,0.0005448673,1.649204e-7,0.0008272672,0.00001530295,0.00004431787,0.00006365146,0.00005342219,0.0001733967],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857221,0.002808075,0.000002197158,0.001220907,0.0006505615,0.009290025,0.0000209965,0.00007802785,0.0002070554],"genre_scores_gemma":[0.996765,0.0005404459,0.00007797707,0.0006045959,0.0002759877,0.001382938,0.0000110694,0.00002480886,0.0003172184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1147375,"threshold_uncertainty_score":0.9656753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1791815948416946,"score_gpt":0.4088752798345234,"score_spread":0.2296936849928287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}