{"id":"W4416789757","doi":"10.1038/s41598-025-29944-w","title":"Diminished osteoprotegerin production by gingival fibroblasts from periodontitis patients is associated with their reduced ability to suppress osteoclastogenesis","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wydział Lekarski, Uniwersytet Jagielloński Collegium Medicum; Narodowe Centrum Nauki; Uniwersytet Jagielloński w Krakowie; Narodowym Centrum Nauki; Uniwersytet Jagielloński Collegium Medicum","keywords":"Osteoprotegerin; Osteoclast; Periodontitis; Bone resorption; Dental alveolus; RANKL; Resorption; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002429552,0.0002990533,0.0003966852,0.0005245958,0.0002831336,0.0005922692,0.0001077558,0.0003735787,0.002228636],"category_scores_gemma":[0.0002777459,0.0001578508,0.0004042477,0.0004060906,0.000239989,0.0001308414,0.0002915351,0.0005125487,0.0005405842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001467203,"about_ca_system_score_gemma":0.0002527218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133416,"about_ca_topic_score_gemma":0.001621584,"domain_scores_codex":[0.9997607,0.00001689804,0.00002468283,0.00006293444,0.00007975324,0.00005510875],"domain_scores_gemma":[0.9998839,0.00002053547,0.00003620161,0.00001203286,0.00002229878,0.00002498329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001050305,0.00004845033,0.01198046,0.0003213874,0.00005476358,0.0004902442,0.0001361602,0.0001048375,0.9753396,0.00004611208,0.000508139,0.009919576],"study_design_scores_gemma":[0.0002785488,0.000872085,0.5589311,0.0001913797,0.0004072645,0.006557883,0.001746241,0.001937776,0.4079464,0.0007701681,0.02027002,0.00009105821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984608,0.006830018,0.001791682,0.0001817823,0.00007750772,0.00004170945,0.005399115,0.00008809586,0.0009821279],"genre_scores_gemma":[0.9887456,0.002877836,0.001823142,0.0002348901,0.0000362149,0.00009727184,0.00495034,0.00002421867,0.001210449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002228636,"threshold_uncertainty_score":0.007455587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004001157584109843,"score_gpt":0.2046852296221268,"score_spread":0.200684072038017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}